PMS2 Antibody

• Catalog number
  3455-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  PMS2
• Target Alternative Name
  HNPCC4 , PMS2CL , PMSL2 , DNA mismatch repair gene homologue H_DJ0042M02.9
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 846 of human PMS2
• Accession
  P54278
• Gene Id
  5395
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot, Immunohistochemistry
• Application And Usages
  Western blotting (0.5-4 µg/ml), immunoprecipitation (10-20 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually.
• Description
  Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10-45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to sμggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PMS2  
• Gene symbol
  PMS2
• Short name
  PMS2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  PMS2 postmeiotic segregation increased 2 (S. cerevisiae), HNPCC4 and PMS2CL and PMSL2, PMS2 and IDBG-7921 and ENSG00000122512 and 5395, MutSalpha complex binding, nuclei, Pms2 and IDBG-259679 and ENSMUSG00000079109 and 18861, PMS2 and IDBG-640975 and ENSBTAG00000007364 and 527039

Gene info

• Identity
  HGNC:9122
• Gene
  PMS2
• Long gene name
  PMS1 homolog 2, mismatch repair system component
• Synonyms gene
  • PMSL2
• Synonyms gene name
  • postmeiotic segregation increased (S. cerevisiae) 2
  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
  • PMS1 homolog 2, mismatch repair protein
• Synonyms
  • H_DJ0042M02.9
  • HNPCC4
  • MLH4
• Locus
  7p22.1
• Discovery year
  1994-12-13
• Entrez gene record
  5395
• Pubmed identfication
  • 8072530
• RefSeq identity
  • NM_000535
• Classification
  • MutL homologs
• VEGA ID
  OTTHUMG00000023135
• Locus Specific Databases
  • Hereditary Non-Polyposis Colorectal Cancer, HNPCC
  • Global Variome shared LOVD
  • PMS2 database at LOVD-China
  • LRG_161

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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