anti-PDIA1 Antibody

• Catalog number
  8213
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  PDIA1 (protein disulfide isomerase family A member 1) is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen (1,2). PDIA1 is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds (3). Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex (4).
• Gene names
  Protein disulfide isomerase family A member 1, DSI, GIT, PDI, PHDB, PO4DB, PO4HB, PROHB, ERBA2L, P4Hbeta
• Antibodie s label
  unlabelled serum
• Purity
  PDIA1 antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  PDIA1 antibody is human, mouse and rat reactive.
• Antigen
  PDIA1 antibody was made against a 17 amino acid peptide near the center of human PDIA1.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  PDIA1 antibody can be used for detection of PDIA1 by Western blot at 1 - 2 ug/ml.
• Suspention pH azide
  PDIA1 antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  PDIA1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  20070125
• Ncbi nr
  NP_000909
• KDa
  Predicted: 54 kDa Observed: 54 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  5034
• GENE symbol
  P4HB
• Antigene name
  prolyl 4-hydroxylase, beta polypeptid
• Source
  homo sapiens
• Protein nr
  P07237
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PDIA1  
• Gene symbol
  P4HB
• Short name
  anti-PDIA1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toPDIA1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8548
• Gene
  P4HB
• Long gene name
  prolyl 4-hydroxylase subunit beta
• Synonyms gene
  • PO4DB
  • ERBA2L
• Synonyms gene name
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
  • prolyl 4-hydroxylase, beta polypeptide
• Synonyms
  • PDIA1
  • PROHB
  • DSI
  • GIT
  • PDI
  • PO4HB
  • P4Hbeta
• Synonyms name
  • protein disulfide isomerase-associated 1
  • protein disulfide isomerase family A, member 1
  • collagen prolyl 4-hydroxylase beta
• GenBank acession
  • J02783
• Locus
  17q25.3
• Discovery year
  1986-01-01
• Entrez gene record
  5034
• Pubmed identfication
  • 8111381
• RefSeq identity
  • NM_000918
• Classification
  • Protein disulfide isomerases
• VEGA ID
  OTTHUMG00000150269

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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