anti-MRE11 Antibody

• Catalog number
  5547
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  MRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.
• Gene names
  MRE11 Antibody: ATLD, HNGS1, MRE11, MRE11B, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1
• Antibodie s label
  unlabelled serum
• Purity
  MRE11 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  MRE11 antibody was made against a 14 amino acid synthetic peptide from near the amino terminus human MRE11.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  MRE11 antibody can be used for detection of MRE11 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  MRE11 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  MRE11 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  119587336
• Ncbi nr
  EAW66932
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  4361
• GENE symbol
  MRE11A
• Antigene name
  MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
• Source
  Homo sapiens
• Protein nr
  P49959
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MRE11  
• Gene symbol
  MRE11
• Short name
  anti-MRE11 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMRE11 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7230
• Gene
  MRE11
• Long gene name
  MRE11 homolog, double strand break repair nuclease
• Synonyms gene
  • MRE11A
• Synonyms gene name
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • MRE11 homolog A, double strand break repair nuclease
• Synonyms
  • ATLD
• Synonyms name
  • AT-like disease
• GenBank acession
  • BC063458
• Locus
  11q21
• Discovery year
  1995-05-05
• Entrez gene record
  4361
• Pubmed identfication
  • 8530104
  • 24316220
• RefSeq identity
  • NM_005591
• Classification
  • MRN complex
  • MicroRNA protein coding host genes
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000167780
• Locus Specific Databases
  • MRE11Abase: Mutation registry for Ataxia-telangiectasia-like disorder (ATLD)
  • LRG_85

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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