Anti-Mre11 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-3503R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  Mre11
• Specificity
  This antibody reacts specifically with Mre11
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Nucleus
• Antigen Source
  KLH conjugated synthetic peptide derived from human Mre11/HNGS1
• Gene ID
  4361
• Swiss Prot
  P49959
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  ATLD; HNGS1; MRE11; MRE11B; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A; MRE11A
• Also known as
  Mre11 Polyclonal Antibody
• Other name
  Anti-Mre11 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  Mre11  
• Gene symbol
  MRE11, MRE11P1
• Short name
  Anti-Mre11
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Mre11 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:7230
• Gene
  MRE11
• Long gene name
  MRE11 homolog, double strand break repair nuclease
• Synonyms gene
  • MRE11A
• Synonyms gene name
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • MRE11 homolog A, double strand break repair nuclease
• Synonyms
  • ATLD
• Synonyms name
  • AT-like disease
• GenBank acession
  • BC063458
• Locus
  11q21
• Discovery year
  1995-05-05
• Entrez gene record
  4361
• Pubmed identfication
  • 8530104
  • 24316220
• RefSeq identity
  • NM_005591
• Classification
  • MRN complex
  • MicroRNA protein coding host genes
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000167780
• Locus Specific Databases
  • MRE11Abase: Mutation registry for Ataxia-telangiectasia-like disorder (ATLD)
  • LRG_85

Gene info

• Identity
  HGNC:7231
• Gene
  MRE11P1
• Long gene name
  MRE11 homolog, double strand break repair nuclease pseudogene 1
• Synonyms gene
  • MRE11B
• Synonyms gene name
  • meiotic recombination (S. cerevisiae) 11 homolog B
  • MRE11 meiotic recombination 11 homolog B (S. cerevisiae)
  • MRE11 double strand break repair nuclease B (pseudogene)
  • MRE11 homolog B, double strand break repair nuclease (pseudogene)
• GenBank acession
  • AF307006
• Locus
  3q25.31
• Discovery year
  1997-10-10
• Entrez gene record
  4362
• Pubmed identfication
  • 11371508
• RefSeq identity
  • NG_001157
• VEGA ID
  OTTHUMG00000158550

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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