Anti-Mouse EphA4 is available 1 time from Reliatech antibodies labs
- Gene NameEphA4
- Species ReactivityMouse (Mus musculus)
- SynonymsEpha4; rb; Sek; Cek8; Hek8; Sek1; Tyro1; AI385584; 2900005C20Rik
- DescriptionThis is a highly purified antibody with strong binding affinity towards the antigen that it has been risen against.Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in.
- Storage and handlingLyophilized antibodies can be shipped at ambient temperature and stored for short terms at +4 degrees Celsius and at -20 for long term storage. Reconstituted lyophilised and antibodies in liquid form can be shipped and stored for short terms at +4 degrees Celsius. Generally, it is recomended for long term storage (up to one year) 25-50% glycerol or ethylene glycol to be added and the vial must be stored at -20°C.
- AdvisoryIn order to retain the quality and the affinity of the antibodies unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
- Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
- TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
- Latin nameMus musculus
- Gene target
- Short nameAnti-Mouse EphA4
- TechniqueMouse, anti
- Alternative nameantibody to-Mouse EphA4
- Alternative techniqueantibodies
103-M166 | Anti-Mouse EphA4size: 100ug | 413.82 USD
- Catalog number103-M166
- Price413.82 USD
1. Gene info
- Long gene nameEPH receptor A4
- Synonyms gene
- Synonyms gene name
- GenBank acession
- Discovery year1992-10-02
- Entrez gene record
- Pubmed identfication
- Sterile alpha motif domain containing
- Fibronectin type III domain containing
- EPH receptors
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedEphrin-A3 is localized on astrocytic processes that envelop spines. Activation of EphA4 by ephrin-A3 caused spine retraction; inhibiting ephrin/EphA4 interactions distorted spine shape and organization in hippocampal slices.These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits.These results support a model in which EphA4 interferes with integrin signaling pathways that stabilize dendritic spines, thus modulating synaptic interactions with the extracellular environment.Each of the principal guidance decisions within both anterior and posterior tracts of the anterior commissure can be accounted for by the individual and combinatorial actions of EphB2/A4 receptors.This study reveals a novel mechanism to regulate guidance decision at an intermediate target based on the modulation of ligand availability by the proteolytic processing of the receptor.Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model.the results of the present study demonstrated that angiogenesis occurs, and that the molecules EphA4 and ephrin-A5 are expressed in the hippocampal CA1 and CA3 areas throughout epileptogenesis. PECAM-1 may detect epileptic microvessel patterns in the hippocampi of mice and EphA4 may contribute to the microvessel plasticity via the ephrin-A5 signaling pathway.
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene