MCM4 Antibody

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• Catalog number
  PA1652
• Price:

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• Size
  0,1 mg

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• Target antigen
  MCM4
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat Predicted to work with: mouse
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human MCM4(815-829aa TPALKYQQLFEDIRG), identical to the related rat and mouse sequences.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the MCM4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The MCM4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  MCM4(MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 4), also called CDC21, S. POMBE, HOMOLOG OF, is a protein that in humans is encoded by the MCM4 gene. MCM4 is one of the highly conserved mini-chromosome maintenance proteins(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM4 gene is mapped to 8q11.21. The 864-amino acid MCM4 protein has an observed molecular mass of 97 kD by SDS-PAGE, which is similar to its calculated molecular mass of 96.6 kD. Western blot analysis with and without phosphatase treatment suggested that MCM4 is highly phosphorylated in mitotic cells. In the absence of DDK, CDK phosphorylation at the distal part of the Mcm4 NSD becomes crucial.MCM4 encodes a subunit of the MCM2-7 complex(also known as MCM2-MCM7), the replication licensing factor and presumptive replicative helicase.
• Related articles
  1. Connelly, M. A., Zhang, H., Kieleczawa, J., Anderson, C. W. The promoters for human DNA-PK(cs) (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. Genomics 47: 71-83, 1998. 2. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of replication fork progression through histone supply and demand. Science 318: 1928-1931, 2007. 3. Hu B, Burkhart R, Schulte D et al (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Nucleic Acids Res. 21 (23): 5289–93.
• Gene Name
  MCM4
• Protein Name
  DNA replication licensing factor MCM4
• Gene Full Name
  minichromosome maintenance complex component 4
• Synonyms
  19G antibody|AI325074 antibody|AU045576 antibody|CDC 21 antibody|CDC 54 antibody|CDC21 antibody|CDC21 homolog antibody|CDC21, S. pombe, homolog of antibody|CDC54 antibody|Cell division cycle 21, S. pombe, homolog of antibody|DNA replication licensing factor MCM 4 antibody|DNA replication licensing factor MCM4 antibody|hCdc 21 antibody|hCdc21 antibody|Homolog of S. pombe cell devision cycle 21 antibody|KIAA4003 antibody|mcdc21 antibody|MCM 4 antibody|MCM 4 minichromosome maintenance deficient 4 antibody|MCM4 antibody|MCM4 minichromosome maintenance deficient 4 antibody|MCM4 minichromosome maintenance deficient 4, mitotin(S. cerevisiae) antibody|MCM4_HUMAN antibody|Mcmd4 antibody|MGC33310 antibody|Minichromosome Maintenance 4 antibody|Minichromosome maintenance complex component 4 antibody|Minichromosome maintenance deficient(S. cerevisiae) 4 antibody|Minichromosome maintenance deficient 4 antibody|Minichromosome maintenance deficient 4 homolog(S. cerevisiae) antibody|Minichromosome maintenance, S. cerevisiae, homolog of, 4 antibody|mKIAA4003 antibody|P1 CDC21 antibody|P1-CDC21 antibody|P1CDC21 antibody
• Uniprot ID
  P33991
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

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• Gene target
  MCM4  
• Gene symbol
  MCM4
• Short name
  MCM4 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  MCM4 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6947
• Gene
  MCM4
• Long gene name
  minichromosome maintenance complex component 4
• Synonyms gene
  • CDC21
• Synonyms gene name
  • MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)
• Synonyms
  • CDC54
  • hCdc21
  • P1-Cdc21
  • MGC33310
• Synonyms name
  • DNA replication licensing factor MCM4
• Locus
  8q11.21
• Discovery year
  1994-12-13
• Entrez gene record
  4173
• Pubmed identfication
  • 7601140
• RefSeq identity
  • NM_005914
• Classification
  • minichromosome maintenance 2-7 complex
  • MCM family
• VEGA ID
  OTTHUMG00000164205
• Locus Specific Databases
  • LRG_1239

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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