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anti-LIMK2 Antibody

anti-LIMK2 Antibody is available 1 time from Biovision labs

3584-100 | anti-LIMK2 Antibody size: LIMK2 Antibody | 391.44 USD

Catalog number 3584-100
Supplier Biovision
Price391.44 USD
Size LIMK2 Antibody
1. Gene info
Identity6614
GeneLIMK2
Long gene name LIM domain kinase 2
GenBank acession
Locus22q12.2
Discovery year 1997-08-28
Entrez gene record3985
Pubmed identfication
RefSeq identity
Classification
  • LIM domain containing
  • PDZ domain containing
Havana BLAST/BLATOTTHUMG00000151251
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedthere were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in metabolic syndrome patients.
LIMK1 may play a role different from that of LIMK2 in regulating mitotic spindle organization, chromosome segregation, and cytokinesis during the cell division cycle.
Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay.
a novel pathway whereby LIMK2b, acting downstream of p53, ensures proper execution of checkpoint arrest by modulating the dynamics of actin polymerization
This study reveals novel connections between actin cytoskeleton regulators and p53-mediated cell survival mechanisms.
a novel pathway emanating from the TGF-beta type I receptor and leading to regulation of actin assembly, via the kinase LIMK2.
LIMK2 positively regulates the level of Aurora A, thereby engaging in a positive-feedback loop, promoting Aurora-A-mediated oncogenic pathways.
Nf1/LIMK2 interaction and inhibition allows to directly connect neurofibromatosis type I to actin cytoskeleton remodeling.
results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers
LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase, inflammation mediated by chemokine and cytokine signaling pathways, T cell activation, and angiogenesis.
Gene ontology - Cellular componentnucleus
cytoplasm
cis-Golgi network
Entrez GeneLIM domain kinase 2  (LIMK2)  (PDLIM5)
Product images
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This antibody has been succesfully tested for use in following methods: Western blot
Target of this antibody: LIMK2
Formulation of this antibody: 100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Alternative names of antibody target: EC 2.7.11.1 , LIMK-2 , LIM domain kinase 2 , LIMK
Recommended usage: Western blotting (1-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 70 kDa LIMK2 protein. It does not cross-react with LIMK1.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
Antibody host: Rabbit
This antibody reacts with: Human, mouse, rat
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
Purification method: Affinity purified
Immunogene sequence: Synthetic peptide corresponding to the C-terminus of human LIMK2
How to handle this antibody: The antibody solution should be gently mixed before use.
Background information: LIM kinases (LIMK1 and LIMK2) are serine/threnine kinases that have two zinc finger motifs, known as LIM motifs in their N-terminal regulatory domain. LIM kinases are involved in actin cytoskeleton regulation throμgh Rho-family GTPases and downstream kinases PAKs and ROCK. PAK1 and ROCK phosphorylate LIMK1 and LIMK2, which increases the activity of the kinases. Activated LIM kinases inhibit the actin depolymerization activity of cofilin by phosphorylation at the N-terminus of Cofilin.
Form of antibody: Liquid
Concentration of antibody: 0.5 mg/ml
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetLIMK2
Short name anti-LIMK2 Antibody
Technique Antibody, anti
Alternative name antibody to-LIMK2 (Antibody to)
Alternative technique antibodies
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