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Alternative name1
Anti-RABBIT ANTI HUMAN PHOSPHODIESTERASE 1C (C-TERMINAL)
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Alternative name2
RABBIT ANTI HUMAN PHOSPHODIESTERASE 1C (C-TERMINAL)
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Alternative name3
Lapin ANTI Homo sapiens PHOSPHODIESTERASE 1C (C-TERMINAL)
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Alternative name4
PHOSPHODIESTERASE 1C
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Alternative name5
N/A
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Other names
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; hCam-3; cam-PDE 1C; Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); phosphodiesterase 1C, calmodulin-dependent 70kDa; hCam-3
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Gene name
N/A
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Gene name synonims
N/A
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Other gene names
PDE1C; PDE1C; Hcam3; Cam-PDE 1C
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Human
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Specificity and cross reactivity
PHOSPHODIESTERASE 1C This item detects an epitope within the C-terminal (CT) region of phosphodiesterase 1C (PDE1C), a subtype of the PDE1 enzyme. PDE1C is activated by calmodulin binding in the presence of calcium, and degrades the cyclic nucleotides cAMP and cGMP. A number of PDE1C isoforms exist, each with different affinities for cAMP and cGMP. They have a range of molecular weights from 65-70kD. _x000D__x000D_PDE1C is a major regulator of smooth muscle cell (SMC) proliferation in humans, and plays an important role in the development of organs containing smooth muscle. PDE1C may also have a role in olfaction, regulation of sperm function and neuronal signaling. _x000D__x000D_Inhibition of PDE1C may prove beneficial in the treatment of diseases such as atherosclerosis and pulmonary hypertension where excessive SMC proliferation occurs.
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
IgG concentration 0.1 miligram per 1 mililiter
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Immunohistology - Paraffin (IHC)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
MBS Polyclonals supplies antibodies that are for research of human proteins.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
