FOXA2/HNF 3beta Antibody, ALEXA FLUOR 594
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Catalog number
bs-2358R-A594
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Price
Please ask
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Size
100ul
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Long name
FOXA2/HNF 3beta Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known as
Anti-FOXA2/HNF 3beta PAb ALEXA FLUOR 594
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 594
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
FOXA2/HNF 3beta
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Specificity
This is a highly specific antibody against FOXA2/HNF 3beta.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
200-250/457
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Subcellular location
Cytoplasm, Nucleus
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HNF 3 beta
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Gene ID Number
3170
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Swiss Prot
Q9Y261
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Tested applications
FCM, IF(IHC-P)
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Recommended dilutions
FCM(1:20-100), IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
590nm/617nm
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Synonyms
HNF3B; TCF3B; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA2
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Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR® 594
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Conjugated
Alexa conjugate 1
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French translation
anticorps
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Gene target
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Gene symbol
FOXA2, ONECUT1, FOXM1
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Short name
Anti-FOXA2/HNF 3beta
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 594
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Alternative name
FOXA2/HNF 3beta Polyclonal Antibody, ALEXA FLUOR 594
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Alternative technique
antibodies
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Alternative to gene target
forkhead box A2, HNF3B and TCF3B, FOXA2 and IDBG-59234 and ENSG00000125798 and 3170, transcription regulatory region DNA binding, nuclei, Foxa2 and IDBG-208945 and ENSMUSG00000037025 and 15376, FOXA2 and IDBG-648756 and ENSBTAG00000012407 and 503580
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Gene info
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Identity
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Gene
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Long gene name
forkhead box A2
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Synonyms gene
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Synonyms gene name
- hepatocyte nuclear factor 3, beta
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GenBank acession
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Locus
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Discovery year
1998-02-11
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Entrez gene record
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Pubmed identfication
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
one cut homeobox 1
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Synonyms gene
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Synonyms gene name
- one cut domain, family member 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
2000-02-11
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Entrez gene record
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Pubmed identfication
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Classification
- CUT class homeoboxes and pseudogenes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
forkhead box M1
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1997-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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