CD105/Endoglin Antibody (Center E395)
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Catalog number
6800-100
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Price
Please ask
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Size
100 μl
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Antibody Target
CD105
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Target Alternative Name
ENG; END; Endoglin
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Antibody Type
Polyclonal
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Species Reactivities
Human, Mouse.
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Immunogen Sequence
This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.
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Accession
P17813
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Gene Id
2022
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In PBS with 0.09% (W/V) sodium azide.
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Purification
Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
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Application
Western blot, IHC, FACS.
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Positive Control
Western blot: Mouse heart tissue lysate, IHC: mouse heart tissue, FACS: NCI-H292.
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Application And Usages
WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
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Description
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
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Storage Condition
-20 °C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Verified
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Immunocytochemistry Verified
Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Flow Cytometry Verified
Verified
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ENG
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Short name
CD105/Endoglin Antibody (Center E395)
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Rabbit IgG
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Alternative name
CD105/Endoglin (antibody to-) (central E395)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
endoglin
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Synonyms gene
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Synonyms gene name
- Osler-Rendu-Weber syndrome 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
1993-03-03
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Entrez gene record
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Pubmed identfication
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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