anti-CBX3 Antibody

anti-CBX3 Antibody is available 1 time from Biovision labs

6147-100 | anti-CBX3 Antibodysize: CBX3 Antibody | 471.59 USD

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  • Target of this antibody:
    CBX3
  • Alternative names of antibody target:
    HECH, HP1­GAMMA, HP1Hs­gamma, HP1γ
  • Background information:
    Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; However, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino terminal chromodomain, followed by a variable hinge region and a conserved carboxy­terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri­methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin. The variable hinge region binds both RNA and DNA in a sequence independent manner. The chromoshadow domain mediates the dimerization of HP1 proteins, in addition to binding multiple proteins  implicated in gene silencing and heterochromatin  formation, including the SUV39H histone methyltransferase, the DNMT1 and DNMT3a DNA  methyltransferases, and the p150 subunit of chromatin­assembly factor­1 (CAF1). In addition to contributing to heterochromatin formation and propagation, HP1 and SUV39H are also found complexed with retinoblastoma (Rb) and E2F6 proteins, both of which function to repress euchromatic gene transcription in quiescent cells. HP1 proteins are subject to multiple types of post­translational modifications, including phosphorylation, acetylation, methylation, ubiquitination, and sumoylation, suggesting multiple means of regulation.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • This antibody reacts with:
    Human, mouse, rat
  • Immunogene sequence:
    Fusion protein of human CBX3
  • Concentration of antibody:
    1 mg/ml
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
  • Purification method:
    Affinity purified
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunohistochemistry, Immunofluorescene
  • Recommended usage:
    Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:100, IF: 1:20 – 1:50
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-CBX3 Antibody
  • Technique
    Antibody, anti
  • Alternative name
    antibody to-CBX3 (Antibody to)
  • Alternative technique
    antibodies
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