anti-BMPR2 Antibody (NT)

anti-BMPR2 Antibody (NT) is available 1 time from Biovision labs

6780-100 | anti-BMPR2 Antibody (NT)size: BMPR2 Antibody (NT) | 397.45 USD

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  • Target of this antibody:
    BMPR2
  • Alternative names of antibody target:
    BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II
  • Background information:
    BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Clone:
    N/A
  • This antibody reacts with:
    Human, Mouse.
  • Immunogene sequence:
    This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.
  • Concentration of antibody:
    N/A
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    In PBS with 0.09% (W/V) sodium azide.
  • Purification method:
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
  • This antibody has been succesfully tested for use in following methods:
    Western blot, IHC, FACS.
  • Recommended usage:
    WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-BMPR2 Antibody (NT)
  • Technique
    Antibody, anti
  • Alternative name
    antibody to-bone morphogenetic protein receptor, classification II (serine/threonine kinase) (Antibody to) (NT)
  • Alternative technique
    antibodies
  • Alternative to gene target
    bone morphogenetic protein receptor, type II (serine/threonine kinase), BMPR-II and BMPR3 and BMR2 and BRK-3 and POVD1 and PPH1 and T-ALK, BMPR2 and IDBG-78880 and ENSG00000204217 and 659, activin receptor activity, Extracellular, Bmpr2 and IDBG-158574 and ENSMUSG00000067336 and 12168, BT.25715 and IDBG-643309 and ENSBTAG00000006420 and 407127
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