anti-BDNF Antibody
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Catalog numberXP-5108Bt
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PricePlease ask
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Size0.05 mg
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Gene infoBrain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients. In addition, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart.
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Gene namesANON2, BULN2Brain-derived neurotrophic factor, Abrineurin, BDNF
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Antibodie s labelBiotin
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PurityAnti-hBDNF specific antibody was purified by affinity chromatography and then biotinylated.
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Ab raised inRabbit
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TypePolyclonal
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AntigenProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBDNF (human BDNF).
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Immuno applicationELISA, Western Blot
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Antibody adviceELISA:To detect hBDNF by direct ELISA (using 100 μL/well antibody solution) this antibody can be used at a concentration of 0.15 - 0.30 ug/mL. Used in conjunction with compatible secondary reagents, allows the detection of at least 0.2 ng/well of recombinant hBDNF. Western Blot:To detect hBDNF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBDNF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
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Keep atBDNF antibody is stable for at least 2 years from date of receipt at -20 grades C. The reconstituted antibody is stable for at least two weeks at 2-8 grades C. Frozen aliquots are stable for at least 6 months when stored at -20 grades C. Avoid repeated freeze-thaw cycles.
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Works withHuman
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Omim nr114900
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Ncbi nrP23560
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Vial with antibodyLyophilized
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NCBI GENE nr627
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GENE symbolBDNF
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Antigene namebrain-derived neurotrophic factor
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SourceHomo sapiens
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Protein nrP23560
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolBDNF, BDNF-AS
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Short nameanti-BDNF Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toBDNF (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetbrain-derived neurotrophic factor, ANON2 and BULN2, BDNF and IDBG-36817 and ENSG00000176697 and 627, growth factor activity, Extracellular, Bdnf and IDBG-195506 and ENSMUSG00000048482 and 12064, BDNF and IDBG-636102 and ENSBTAG00000008134 and 617701
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Gene info
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Identity
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Gene
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Long gene namebrain derived neurotrophic factor
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-01-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Neurotrophins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameBDNF antisense RNA
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Synonyms gene
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Synonyms gene name
- BDNF opposite strand (non-protein coding)
- BDNF antisense RNA (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-02-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data