anti-BACE2 Antibody
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Catalog number2247
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoBACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
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Gene namesBACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1
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Antibodie s labelunlabelled serum
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PurityBACE2 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenBACE2 antibody was made against a 16 amino acid peptide near the amino terminus of human BACE2.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry
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Antibody adviceBACE2 can be used for detection of BACE2 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 10 ug/mL.
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Suspention pH azideBACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atBACE2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr6561812
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Ncbi nrAAF17078
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Vial with antibodyin solution
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NCBI GENE nr25825
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GENE symbolBACE2
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Antigene namebeta-site APP-cleaving enzyme 2
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SourceHomo sapiens
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Protein nrQ9Y5Z0
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolBACE2-IT1, BACE2
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Short nameanti-BACE2 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toBACE2 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameBACE2 intronic transcript 1
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Synonyms gene
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Synonyms gene name
- chromosome 21 open reading frame 75
- non-protein coding RNA 228
- BACE2 intronic transcript 1 (non-protein coding)
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Synonyms
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Locus
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Discovery year2002-11-26
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Entrez gene record
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Classification
- Intronic transcripts
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebeta-secretase 2
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Synonyms gene
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Synonyms gene name
- beta-site APP-cleaving enzyme 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-05-23
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Entrez gene record
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Pubmed identfication
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Classification
- Peptidase family A1
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
