Anti-ATG5-ATG12 COMPLEX (C-TERMINAL)

• Catalog number
  MBS224276
• Price
  Please ask
• Size
  100ug

• Alternative name1
  Anti-RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)
• Alternative name2
  RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)
• Alternative name3
  Lapin ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)
• Alternative name4
  ATG5-ATG12 COMPLEX
• Alternative name5
  N/A
• Other names
  ubiquitin-like protein ATG12 isoform 1; Ubiquitin-like protein ATG12; ubiquitin-like protein ATG12; Apg12 (autophagy, yeast) homolog; ATG12 autophagy related 12 homolog; autophagy related 12; Autophagy-related protein 12
• Gene name
  N/A
• Gene name synonims
  N/A
• Other gene names
  ATG12; ATG12; APG12; FBR93; APG12L; HAPG12; APG12; APG12L; APG12-like
• Category
  Antibodies
• Clonality
  Polyclonal
• Immunoglobulin isotype
  Polyclonal IgG
• Clone
  Polyclonal antibody
• Host organism
  Rabbit
• Species reactivity
  Mouse
• Specificity and cross reactivity
  ATG5-ATG12 COMPLEX This item specifically recognises an epitope within the C-Terminal (CT) region of the Atg5-Atg12 complex, which plays a key role in the regulation of autophagy, and is emerging as an important factor in the innate immune response to viruses. _x000D__x000D_Studies have shown that the Atg5-Atg12 complex directly interacts with RIG-1 (retinoic acid-inducible gene 1) and the adaptor molecule IPS-1 (IFN-beta promoter stimulator 1), through caspase recruitment domains (CARDs), thereby acting as a negative regulator of the type I IFN production pathway, and as a contributor to RNA viral replication within the host cells._x000D_
• Purification method
  N/A
• Form Appearance
  Purified (Purified IgG - liquid)
• Concentration
  IgG concentration 1.0mg/ml
• Storage and shipping
  Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
• Tested for
  Western Blot (WB)
• Description
  productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
• Advisory
  In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.

• Gene target
  ATG5-ATG12   COMPLEX  
• Gene symbol
  ATG12, ATG5
• Short name
  Anti-ATG5-ATG12 COMPLEX (C-TERMINAL)
• Technique
  anti-, anti, antibody to, antibodies
• Alternative name
  Antibody toATG5-ATG12 aggregate (C-TERMINAL)
• Alternative technique
  antibodies
• Alternative to gene target
  autophagy related 5, APG5 and APG5-LIKE and APG5L and ASP and hAPG5, ATG5 and IDBG-94856 and ENSG00000057663 and 9474, protein binding, Plasma membranes, Atg5 and IDBG-148568 and ENSMUSG00000038160 and 11793, ATG5 and IDBG-631895 and ENSBTAG00000005400 and 532686

Gene info

• Identity
  HGNC:588
• Gene
  ATG12
• Long gene name
  autophagy related 12
• Synonyms gene
  • APG12L
• Synonyms gene name
  • Apg12 (autophagy 12, S. cerevisiae)-like
  • APG12 autophagy 12-like (S. cerevisiae)
  • ATG12 autophagy related 12 homolog (S. cerevisiae)
• Synonyms
  • APG12
• Synonyms name
  • APG12 autophagy 12-like
• GenBank acession
  • AB017507
• Locus
  5q22.3
• Discovery year
  1999-10-01
• Entrez gene record
  9140
• Pubmed identfication
  • 9852036
• RefSeq identity
  • NM_004707
• Classification
  • Autophagy related
• VEGA ID
  OTTHUMG00000128889

Gene info

• Identity
  HGNC:589
• Gene
  ATG5
• Long gene name
  autophagy related 5
• Synonyms gene
  • APG5L
• Synonyms gene name
  • APG5 (autophagy 5, S. cerevisiae)-like
  • APG5 autophagy 5-like (S. cerevisiae)
  • ATG5 autophagy related 5 homolog (S. cerevisiae)
• Synonyms
  • ASP
  • APG5
  • hAPG5
• GenBank acession
  • Y11588
• Locus
  6q21
• Discovery year
  1999-09-16
• Entrez gene record
  9474
• Pubmed identfication
  • 9563500
  • 11349150
  • 15778222
• RefSeq identity
  • NM_004849
• Classification
  • Autophagy related
• VEGA ID
  OTTHUMG00000016193

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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