Anti-TXK Antibody
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Catalog numberA1203-100
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PricePlease ask
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Size100 µl
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Antibody TargetTXK
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Target Alternative NamePTK4; RLK; Tyrosine-protein kinase TXK; Protein-tyrosine kinase 4; Resting lymphocyte kinase
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Antibody TypePolyclonal
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Species ReactivitiesHuman, Mouse, Rat
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Immunogen SequenceKLH-conjugated synthetic peptide encompassing a sequence within the center region of human TXK
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AccessionP42681
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Gene Id7294
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AppearanceColorless liquid
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FormLiquid
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FormulationIn 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
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PurificationAffinity purified
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ApplicationWB, IH
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Positive ControlWB: Jurkat, THP1, mouse spleen, rat spleen lysate; IHC: human placenta tissue section
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Application And UsagesWB; 1:500 – 1:2000, IHC; 1:50 – 1:200
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DescriptionNon-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates.
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans
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HandlingThe antibody solution should be gently mixed before use
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedVerified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTXK
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Short nameAnti-TXK Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibody toTXK (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetTXK tyrosine kinase, BTKL and PSCTK5 and PTK4 and RLK and TKL, TXK and IDBG-17234 and ENSG00000074966 and 7294, transferase activity, nuclei, Txk and IDBG-170081 and ENSMUSG00000054892 and 22165, TXK and IDBG-642080 and ENSBTAG00000005055 and 504782
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Gene info
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Identity
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Gene
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Long gene nameTXK tyrosine kinase
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Synonyms gene
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Synonyms gene name
- PTK4 protein tyrosine kinase 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-12-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tec family tyrosine kinases
- SH2 domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data