Angiopoietin 1 Antibody

• Catalog number
  R30398
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Angiopoietin 1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, ELISA
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,ELISA: 0.1-0.5ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Angiopoietin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Angiopoietin 1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q15389
• Purity
  Antigen affinity
• Description
  Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Endothelial Tie2/Tek ligands angiopoietin-1(ANGPT1) and angiopoietin-2(ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23.
• Immunogen
  Amino acids 225-239 (RQTYIIQELEKQLNR-human) were used as the immunogen for this Angiopoietin 1 antibody.
• Storage
  After reconstitution, the Angiopoietin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Angiopoietin  
• Gene symbol
  ANGPTL1, ANGPT1, TEK
• Short name
  Anti-Angiopoietin 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Angiopoietin 1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:489
• Gene
  ANGPTL1
• Long gene name
  angiopoietin like 1
• Synonyms gene
  • ANGPT3
• Synonyms gene name
  • angiopoietin-like 1
• Synonyms
  • ANG3
  • AngY
  • ARP1
• Synonyms name
  • angioarrestin
• GenBank acession
  • AF107253
• Locus
  1q25.2
• Discovery year
  2000-02-07
• Entrez gene record
  9068
• Pubmed identfication
  • 10025962
  • 9286704
• RefSeq identity
  • NM_004673
• Classification
  • Fibrinogen C domain containing
  • Receptor ligands
  • Angiopoietin like family
• VEGA ID
  OTTHUMG00000035075

Gene info

• Identity
  HGNC:484
• Gene
  ANGPT1
• Long gene name
  angiopoietin 1
• Synonyms
  • KIAA0003
  • Ang1
• GenBank acession
  • D13628
• Locus
  8q23.1
• Discovery year
  1997-04-10
• Entrez gene record
  284
• Pubmed identfication
  • 9545648
• RefSeq identity
  • NM_001146
  • NM_139290
• Classification
  • Fibrinogen C domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000164812

Gene info

• Identity
  HGNC:11724
• Gene
  TEK
• Long gene name
  TEK receptor tyrosine kinase
• Synonyms gene
  • VMCM
• Synonyms gene name
  • venous malformations, multiple cutaneous and mucosal
  • TEK tyrosine kinase, endothelial
• Synonyms
  • TIE2
  • TIE-2
  • VMCM1
  • CD202b
• Synonyms name
  • angiopoietin-1 receptor
• GenBank acession
  • L06139
• Locus
  9p21.2
• Discovery year
  1994-05-24
• Entrez gene record
  7010
• Pubmed identfication
  • 1312667
  • 7833915
• Classification
  • Receptor tyrosine kinases
  • Fibronectin type III domain containing
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000019712

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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