10-Hydroxycamptothecin
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Catalog numberB1995-100
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PricePlease ask
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Size100 mg
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Alternative_name(S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC107124
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Description10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039). 10-Hydroxycamptothecin displays strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).
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CAS Number19685-09-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₀H₁₆N₂O₅
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Molecular Weight364.35
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO (~3 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent topoisomerase I inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00189425
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PubChem CID97226
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SMILESCCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
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InChiInChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
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InChi KeyHAWSQZCWOQZXHI-FQEVSTJZSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolPIRC49, SNORD115-10, SNORD116-10, IGHV3OR16-10, IGKV2OR2-10, ERVK-10
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Short name10-Hydroxycamptothecin
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Alternative name10-Hydroxycamptothecin
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Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 49
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-10
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-10
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3/OR16-10 (non-functional)
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Synonyms gene name
- immunoglobulin heavy variable 3/OR16-10
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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Classification
- Immunoglobulin heavy (IGH) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2/OR2-10 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 2/OR2-10
- immunoglobulin kappa variable 2/OR2-10 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa (IGK) orphons
Gene info
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Identity
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Gene
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Long gene nameendogenous retrovirus group K member 10
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Synonyms gene name
- endogenous retrovirus group K, member 10
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Synonyms name
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GenBank acession
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Locus
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Discovery year2011-05-05
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Entrez gene record
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Pubmed identfication