Orexin Receptor Type 1 (Ox1r) (human, porcine, rat)

• Catalog number
  T-1524.0200
• Price
  Please ask
• Size
  200ug

• StorageTemperature
  +5 ± 3 °C
• HOST
  Chicken
• Clone
  N/A
• Format
  Purified, liquid
• Species Crossreactivity
  human, porcine, rat
• Application
  IHC
• Conjugate
  NA
• Top Categories
  Antibodies
• Keywords
  Polyclonal; primary antibody
• Additonal Description
  Orexins are endogenous peptides that act through orexin receptor type 1 and type 2, two closely related G-protein-coupled receptors. Binding of orexins to these receptors causes an increase in intracellular calcium levels. In vivo, orexins are involved in the control of feeding behavior and possibly in modulating sleep-wake cycles and other hypothalamic functions. The antibody was generated against a peptide sequence of the second extracellular loop.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Orexin   Receptor   Ox1r  
• Gene symbol
  HCRTR1
• Short name
  Orexin Receptor 1 (Ox1r) ( , porcine, )
• Host
  Rat
• Isotype
  IgY
• Species
  Rat, Humans, Rats
• Alternative name
  Orexin Receptor classification 1 (Ox1r) (H. sapiens, swine, rat)

Gene info

• Identity
  HGNC:4848
• Gene
  HCRTR1
• Long gene name
  hypocretin receptor 1
• Synonyms gene name
  • hypocretin (orexin) receptor 1
• Synonyms
  • OX1R
  • OXR1
  • ORXR1
• Synonyms name
  • orexin receptor 1
• GenBank acession
  • AF041243
• Locus
  1p35.2
• Discovery year
  1998-04-21
• Entrez gene record
  3061
• Pubmed identfication
  • 9491897
• RefSeq identity
  • NM_001525
• Classification
  • Hypocretin receptors
• VEGA ID
  OTTHUMG00000003876

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