Defensin (a1-3) (human) - Clone DEF-3

• Catalog number
  T-1034.0100
• Price
  Please ask
• Size
  100ug

• StorageTemperature
  +5 ± 3 °C
• HOST
  Mouse
• Clone
  DEF-3
• Format
  Purified, Liquid
• Species Crossreactivity
  human
• Application
  IHC, FACS
• Conjugate
  NA
• Top Categories
  Antibodies
• Keywords
  Monoclonal; primary antibody
• Additonal Description
  DEF-3 recognizes a family of cyclic peptides (MW < 3500) in human neutrophils. Four of these peptides (HNP-1 to HNP-4) are described in humans and six (NP-1 to NP-5) in rabbits. The NP-3 is also called corticostatin. In macrophages, synonyms for NP-1 and NP-2 are MCP-1 and MCP-2, respectively. The function of these peptides apart from their bactericidal, antifungal, and monocyte chemotactic functions is the inhibition of ACTH-induced corticosteroid synthesis. DEF-3 is a further marker for inflammation typing. Application: IHC (f, p), FACS Defensin HNP-1 (human) and Defensin HNP-2 (human) are Bachem catalog products (H-9855, H-9005).
• Description
  human, mouse or other beta β- and alpha α- defensins are expressed by neutrophils ( α- ), lymphocytes and epithelial cells. DEFA DEFB genes defend the host against pathogens. GENTAUR supplies anti-defensins, monclonals, polyclonals antisera and recombinant DEFs or peptides of defensin.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  Defensin   a1-3   DEF-3  
• Gene symbol
  RBM6, DEFA3, DEFB127, UTP25, MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12
• Short name
  Defensin (a1-3) ( ) - Clone DEF-3
• Isotype
  IgG1
• Species
  Human, Humans
• Alternative name
  Defensin (a1-3) (H. sapiens) - clonality DEF-3
• Clone name
  DEF-3

Gene info

• Identity
  HGNC:9903
• Gene
  RBM6
• Long gene name
  RNA binding motif protein 6
• Synonyms
  • DEF-3
  • 3G2
  • NY-LU-12
  • g16
  • DEF3
• GenBank acession
  • AF069517
• Locus
  3p21.31
• Discovery year
  1998-09-30
• Entrez gene record
  10180
• Pubmed identfication
  • 10352938
• RefSeq identity
  • NM_005777
• Classification
  • RNA binding motif containing
  • G-patch domain containing
• VEGA ID
  OTTHUMG00000156736

Gene info

• Identity
  HGNC:2762
• Gene
  DEFA3
• Long gene name
  defensin alpha 3
• Synonyms gene
  • DEF3
• Synonyms gene name
  • defensin, alpha 3, neutrophil-specific
• Synonyms
  • HNP-3
• GenBank acession
  • M23281
• Locus
  8p23.1
• Discovery year
  1993-11-05
• Entrez gene record
  1668
• Pubmed identfication
  • 8477861
  • 17214878
  • 15944200
• RefSeq identity
  • NM_005217
• Classification
  • Defensins, alpha
• VEGA ID
  OTTHUMG00000090381

Gene info

• Identity
  HGNC:16206
• Gene
  DEFB127
• Long gene name
  defensin beta 127
• Synonyms gene
  • C20orf73
• Synonyms gene name
  • chromosome 20 open reading frame 73
  • defensin, beta 127
• Synonyms
  • bA530N10.2
  • DEF-27
• GenBank acession
  • AY358796
• Locus
  20p13
• Discovery year
  2001-07-17
• Entrez gene record
  140850
• Pubmed identfication
  • 11854508
• RefSeq identity
  • NM_139074
• Classification
  • Defensins, beta
• VEGA ID
  OTTHUMG00000031617

Gene info

• Identity
  HGNC:28440
• Gene
  UTP25
• Long gene name
  UTP25 small subunit processor component
• Synonyms gene
  • C1orf107
  • DIEXF
• Synonyms gene name
  • chromosome 1 open reading frame 107
  • digestive organ expansion factor homolog (zebrafish)
  • UTP25, small subunit processor component
• Synonyms
  • MGC29875
  • DEF
• GenBank acession
  • BC022964
• Locus
  1q32.2
• Discovery year
  2005-06-03
• Entrez gene record
  27042
• Pubmed identfication
  • 16322560
• RefSeq identity
  • NM_014388
• Classification
  • SSU processome
• VEGA ID
  OTTHUMG00000036654

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37518
• Gene
  PIRC14
• Long gene name
  piwi-interacting RNA cluster 14
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313784
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37516
• Gene
  PIRC12
• Long gene name
  piwi-interacting RNA cluster 12
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313808
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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