Chemerin Receptor (human) - Clone 1A7
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Catalog number
T-1217.0100
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Price
Please ask
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Size
100ug
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Synonym
Chemokine-Like Receptor 1, ChemR23
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StorageTemperature
+5 ± 3 °C
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HOST
Mouse
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Clone
1A7
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Format
Protein G purified; lyophilized
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Species Crossreactivity
human
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Application
IHC
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Conjugate
NA
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Top Categories
Antibodies
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Keywords
Monoclonal; primary antibody
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Additonal Description
UniProt: Q99788. G-protein coupled receptor ChemR23 is a 373 amino acid protein that belongs to the G-protein coupled receptor 1 family, with two potential glycosylation sites and one disulfide bond. The ligand chemerin (or retinoic acid receptor responder protein 2, RARRES2) is a 14 kDa protein found to stimulate chemotaxis of dendritic cells, monocytes/macrophages and natural killer cells to the site of inflammation. Accordingly, there is abundant expression of the receptor on these cells. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue, as well as in tissues associated with hematopoietic and immune function including spleen, thymus, appendix, lymph node, bone marrow and fetal liver. The receptor is also found in adult parathyroid glands, in the cardiovascular system, brain, kidney, gastrointestinal and myeloid tissues and on endothelial cells. ChemR23 acts as a coreceptor for several SIV strains, as well as a primary HIV-1 strain. Application: IHC (p)
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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