CD3 (human) - Clone UCHT-1

StorageTemperature

+5 ± 3 °C
HOST

Mouse
Clone

UCHT-1
Format

Purified, lyophilized
Species Crossreactivity

human
Application

IHC, FACS
Conjugate

NA
Top Categories

Antibodies
Keywords

Monoclonal; primary antibody
Additonal Description

Marker for thymocytes and peripheral T-cells. Monoclonal antibody UCHT-1 recognizes the CD3 antigen on mature human T-cells. The CD3 antigen is a protein complex composed of four distinct chains (CD3?, CD3? and two CD3?) that associate with the T-cell receptor (TCR) and the zeta-chain to generate an activation signal in T lymphocytes. The TCR, zeta-chain and CD3 molecules together comprise the TCR complex. The CD3?, CD3? and CD3? chains are highly related cell surface proteins of the immunoglobulin superfamily containing a single extracellular immunoglobulin domain. Application: IHC (f), FACS
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Gene target

CD3 UCHT-1
Gene symbol

IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1, PIRC1
Short name

CD3 ( ) - Clone UCHT-1
Isotype

IgG2ak
Species

Human, Humans
Alternative name

CD3 (H. sapiens) - clonality UCHT-1
Clone name

UCHT-1

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081