CD20 (human) - Clone CAT13.6E12
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Catalog number
T-1371.0100
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Price
Please ask
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Size
100ug
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StorageTemperature
+5 ± 3 °C
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HOST
Mouse
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Clone
CAT13.6E12
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Format
Purified, lyophilized
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Species Crossreactivity
human
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Application
IHC, FACS
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Conjugate
NA
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Top Categories
Antibodies
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Keywords
Monoclonal; primary antibody
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Additonal Description
Intermediate differentiation stage B-cell marker. Monoclonal antibody CAT13.6E12 recognizes the CD20 antigen. CD20 belongs to the MS4A family (membrane-spanning 4-domains subfamily A). Its expression is restricted to normal and neoplastic B-cells. It is expressed by pre-B-cells in the bone marrow, and expression persists during B-cell maturation but is lost upon terminal differentiation into plasma cells. CD20 is not glycosylated. CD20 is not phosphorylated in resting B-cells, but becomes heavily phosphorylated after mitogen stimulation. Three cell surface isoforms 33, 35 and 37kD, result from differential phosphorylation of a single core 33kD protein within the cytoplasmic domain. Multiple proteins are coimmunoprecipitated with CD20, suggesting that it may be a component of a multimeric surface receptor complex. Monoclonal antibodies against CD20 are used therapeutically, such as Rituximab (Mabthera) or Britumomab (Zevalin). Application: IHC (f), FACS
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Gene info
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