CCRL2 (human) - Clone 1B2
-
Catalog number
T-1230.0200
-
Price
Please ask
-
Size
200ug
-
-
Synonym
C-C Chemokine Receptor-Like 2
-
StorageTemperature
+5 ± 3 °C
-
HOST
Mouse
-
Clone
1B2
-
Format
Protein G purified; lyophilized
-
Species Crossreactivity
human
-
Application
IHC
-
Conjugate
NA
-
Top Categories
Antibodies
-
Keywords
Monoclonal; primary antibody
-
Additonal Description
UniProt: O00421. Lipopolysaccharideinducible CC chemokine receptor (LCCR), or CCRL2 is a 344 amino acid protein that belongs to the G-protein coupled receptor 1 family, with a potential glycosylation site and one disulfide bond. CCRL2 is expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow, but also in lung and heart. CCRL2 is expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4? and CD8?), monocyte-derived iDCs, NK cells, and CD34? progenitor cells, and also on glial cells and mast cells at inflammatory sites. It has been reported to be up-regulated on synovial neutrophils of rheumatoid arthritis patients. Unlike other known G-protein coupled receptors, binding of an agonist such as CCL5 or CCL19 does not induce signal transduction through CCRL2. Rather, the ligand is absorbed after binding, and the receptor recycled, thus reducing the local ligand concentration. The leukocyte chemoattractant chemerin is a ligand for CCRL2 as well, but rather than being recycled, the complex seems to promote bridging to the chemerin receptor on nearby cells. Application: IHC (p)
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Gene target
-
Gene symbol
CCRL2
-
Short name
CCRL2 ( ) - Clone 1B2
-
Isotype
IgG2ak
-
Species
Human, Humans
-
Alternative name
chemokine (C-C motif) receptor-like 2 (H. sapiens) - clonality 1B2
-
Alternative to gene target
chemokine (C-C motif) receptor-like 2, ACKR5 and CKRX and CRAM and CRAM-A and CRAM-B and HCR, CCRL2 and IDBG-30415 and ENSG00000121797 and 9034, CCR chemokine receptor binding, Plasma membranes, Ccrl2 and IDBG-202675 and ENSMUSG00000043953 and 54199, CCRL2 and IDBG-646246 and ENSBTAG00000006155 and 515976
-
Clone name
1B2
-
Gene info
Similar products
