Recombinant Human B7-H2/ICOSLG/CD275 (C-6His)

• Catalog number
  C475-1000
• Price
  Please ask
• Size
  1 mg

• Description
  Recombinant Human Inducible Co-Stimulator Ligand is produced by our Mammalian expression system and the target gene encoding Asp19-Ser258 is expressed with a 6His tag at the C-terminus.
• Species reactivity
  Human
• Origin
  Human Cells
• Peptide sequence
  DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSVDHHHHHH
• Estimated molecular weight
  27,72 kDa
• Protein purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin level
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Shipping condition
  Ambient/Room Temperature
• Package form
  Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Storage conditions
  Lyophilized protein should be stored at below -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at below -20°C for 3 months.
• Reconstitution conditions
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 µg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• UniProt number
  O75144
• Other related products
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  B7-H2/ICOSLG/CD275   C-6His  
• Gene symbol
  ICOSLG, NCAPH2, TUBA3D, HHLA2, RNY4P2, LRRC23, NME2, PCDHGB7, CFB, NCR3LG1
• Short name
  Recombinant B7-H2/ICOSLG/CD275 (C-6His)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Human ICOSLG(C-6His)
• Alternative technique
  rec
• Alternative to gene target
  inducible T-cell co-stimulator ligand, ICOSLG and IDBG-5107 and ENSG00000160223 and 102723996,23308, protein binding, Plasma membranes, Icosl and IDBG-168471 and ENSMUSG00000000732 and 50723, ICOSLG and IDBG-639662 and ENSBTAG00000014880 and 507857

Gene info

• Identity
  HGNC:17087
• Gene
  ICOSLG
• Long gene name
  inducible T cell costimulator ligand
• Synonyms gene
  • ICOSL
• Synonyms gene name
  • inducible T-cell costimulator ligand
• Synonyms
  • KIAA0653
  • GL50
  • B7-H2
  • B7RP-1
  • B7H2
  • B7RP1
  • ICOS-L
  • CD275
  • B7h
• Synonyms name
  • B7-related protein 1
  • B7 homologue 2
  • B7 homolog 2
• GenBank acession
  • AB014553
• Locus
  21q22.3
• Discovery year
  2003-12-12
• Entrez gene record
  23308
• Pubmed identfication
  • 9734811
  • 11007762
• RefSeq identity
  • NM_015259
• Classification
  • B7 family
  • CD molecules
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000086920

Gene info

• Identity
  HGNC:25071
• Gene
  NCAPH2
• Long gene name
  non-SMC condensin II complex subunit H2
• Synonyms gene name
  • non-SMC condensin II complex, subunit H2
• Synonyms
  • 384D8-2
  • hCAP-H2
  • CAP-H2
• Synonyms name
  • kleisin beta
  • CAP-H2 subunit of the condensin II complex
• GenBank acession
  • BC001937
• Locus
  22q13.33
• Discovery year
  2006-09-04
• Entrez gene record
  29781
• Pubmed identfication
  • 10493829
• RefSeq identity
  • NM_152299
• Classification
  • Condensin II subunits
• VEGA ID
  OTTHUMG00000150205

Gene info

• Identity
  HGNC:24071
• Gene
  TUBA3D
• Long gene name
  tubulin alpha 3d
• Synonyms
  • H2-ALPHA
• Synonyms name
  • alpha-tubulin isotype H2-alpha
• GenBank acession
  • K03460
• Locus
  2q21.1
• Discovery year
  2007-02-12
• Entrez gene record
  113457
• Pubmed identfication
  • 3785200
• RefSeq identity
  • NM_080386
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000153600

Gene info

• Identity
  HGNC:4905
• Gene
  HHLA2
• Long gene name
  HERV-H LTR-associating 2
• Synonyms
  • B7H7
  • B7-H5
  • B7y
  • B7-H7
• GenBank acession
  • AF126162
• Locus
  3q13.13
• Discovery year
  1999-09-07
• Entrez gene record
  11148
• Pubmed identfication
  • 10444326
  • 23784006
  • 22488247
• RefSeq identity
  • NM_007072
• Classification
  • C1-set domain containing
  • V-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000159224

Gene info

• Identity
  HGNC:10246
• Gene
  RNY4P2
• Long gene name
  RNY4 pseudogene 2
• Synonyms gene name
  • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
  • RNA, Ro-associated Y4 pseudogene 2
• Synonyms
  • hY4.B7
• GenBank acession
  • M77130
• Locus
  17q21.31
• Discovery year
  1993-08-25
• Entrez gene record
  6088
• RefSeq identity
  • NG_005037

Gene info

• Identity
  HGNC:19138
• Gene
  LRRC23
• Long gene name
  leucine rich repeat containing 23
• Synonyms
  • B7
  • LRPB7
• GenBank acession
  • BC014450
• Locus
  12p13.31
• Discovery year
  2006-01-24
• Entrez gene record
  10233
• Pubmed identfication
  • 11830501
  • 11826754
• RefSeq identity
  • NM_006992
• VEGA ID
  OTTHUMG00000156668

Gene info

• Identity
  HGNC:7850
• Gene
  NME2
• Long gene name
  NME/NM23 nucleoside diphosphate kinase 2
• Synonyms gene name
  • non-metastatic cells 2, protein (NM23B) expressed in
• Synonyms
  • NM23-H2
  • NDPKB
• GenBank acession
  • X58965
• Locus
  17q21.33
• Discovery year
  1991-07-26
• Entrez gene record
  4831
• Pubmed identfication
  • 1988104
  • 19852809
• RefSeq identity
  • NM_002512
• Classification
  • NME/NM23 family
• VEGA ID
  OTTHUMG00000154062

Gene info

• Identity
  HGNC:8714
• Gene
  PCDHGB7
• Long gene name
  protocadherin gamma subfamily B, 7
• Synonyms
  • ME6
  • PCDH-GAMMA-B7
• Synonyms name
  • cadherin ME6
• GenBank acession
  • AF152523
• Locus
  5q31.3
• Discovery year
  2000-06-28
• Entrez gene record
  56099
• Pubmed identfication
  • 10380929
• RefSeq identity
  • NM_018927
• Classification
  • Clustered protocadherins
• VEGA ID
  OTTHUMG00000164054

Gene info

• Identity
  HGNC:1037
• Gene
  CFB
• Long gene name
  complement factor B
• Synonyms gene
  • BFD
  • BF
• Synonyms gene name
  • B-factor, properdin
• Synonyms
  • H2-Bf
• GenBank acession
  • L15702
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  629
• RefSeq identity
  • NM_001710
• Classification
  • Complement system activation components
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000031198
• Locus Specific Databases
  • LRG_136

Gene info

• Identity
  HGNC:42400
• Gene
  NCR3LG1
• Long gene name
  natural killer cell cytotoxicity receptor 3 ligand 1
• Synonyms
  • DKFZp686O24166
  • B7-H6
• Synonyms name
  • B7 homolog 6
• Locus
  11p15.1
• Discovery year
  2012-04-12
• Entrez gene record
  374383
• Pubmed identfication
  • 19528259
• RefSeq identity
  • NM_001202439
• Classification
  • Receptor ligands
  • C1-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000165913

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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