TTF-1 (Thyroid Transcription Factor 1), Homeobox protein Nkx-2.1

Clone

8G7G3/1
Species Reactivity

Rat, Mouse, Human
Product Types

Primary Antibodies
Positive Control

Thyroid or Lung
Immunogen

Recombinant rat TTF-1
Working Concentration

(liquid conc.) 1:10 - 1:50
Concentration

40 µg/ml
Incubation Time

60 min at RT
Application

IHC(P)
Storage

2-8°C
UniProt

P23441 (NKX21_RAT)
Description

Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.

Gene target

TTF-1 Thyroid Transcription Factor Homeobox protein Nkx-2
Gene symbol

NKX2-1, TTF1, RHOH, FOXE1, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1
Short name

TTF-1 (Thyroid Transcription Factor 1), Homeobox protein Nkx-2 1
Host

Mouse
Isotype

IgG1
Alternative name

TTF-1 (Thyroid Transcription Factor 1), Homeobox protein Nkx-2.1
Tissue

thyroid

Identity

HGNC:3806
Gene

FOXE1
Long gene name

forkhead box E1
Synonyms gene
- FKHL15
- TITF2
- FOXE2
Synonyms gene name
- forkhead box E2
- forkhead box E1 (thyroid transcription factor 2)
Synonyms
- TTF-2
- HFKH4
Synonyms name
- thyroid transcription factor 2
GenBank acession
- U89995
Locus

9q22.33
Discovery year

1997-02-14
Entrez gene record

2304
Pubmed identfication
- 9169137
- 9697705
Classification
- Forkhead boxes
VEGA ID

OTTHUMG00000020333

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081