Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT - Blocking Peptide
-
Catalog numberX1690B
-
PricePlease ask
-
Size50 μg
-
-
CategoryProteins & Peptides
-
Long descriptionEndothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.
-
Antibody come fromSynthetic peptide derived from human ceramide kinase protein
-
Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide.
-
Clonenot specified
-
Antigen antibody binding interactionSphingosine 1 Phosphate 3 Receptor (EDG-3) CT - Blocking Peptide
-
Antibody is raised insee techfile
-
Antibody s reacts withsee techfile
-
Antibody s reacts with these speciesThis antibody doesn't cross react with other species
-
Antibody s specificityNo Data Available
-
ApplicationAntibody function blocking
-
Antibody s suited forAntibody can be used for Western blotting (1-10µg/ml). Can also be used for ELISA. Optimal concentration should be evaluated by serial dilutions.
-
Storage-20ºC
-
Relevant references1. Lamour NF, Chalfant CE. ÔCeramide-1-phosphate: The missing link in eicosanoid biosynthesis and inflammation.Õ Mol Interv. 2005 Dec;5(6):358-67. _x000B__x000B_2.Kim JW, Inagaki Y, Mitsutake S, Maezawa N, Katsumura S, Ryu YW, Park CS, Taniguchi M, Igarashi Y. ÔSuppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.Õ Biochim Biophys Acta. 2005 Dec 30;1738(1-3):82-90. Epub 2005 Nov 14. _x000B__x000B_3. Van Overloop H, Gijsbers S, Van Veldhoven PP. ÔFurther characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.Õ_x000B_J Lipid Res. 2006 Feb;47(2):268-83. Epub 2005 Nov 3. _x000B__x000B_4. Chalfant CE, Spiegel S. ÔSphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.Õ J Cell Sci. 2005 Oct 15;118(Pt 20):4605-12. Review. _x000B__x000B_5. Mitsutake S, Igarashi Y. ÔCalmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor.Õ J Biol Chem. 2005 Dec 9;280(49):40436-41. Epub 2005 Oct 3. _x000B__x000B_6. Wijesinghe DS, Massiello A, Subramanian P, Szulc Z, Bielawska A, Chalfant CE. ÔSubstrate specificity of human ceramide kinase.Õ_x000B_J Lipid Res. 2005 Dec;46(12):2706-16. Epub 2005 Sep 18. _x000B__x000B_7.Kim TJ, Mitsutake S, Kato M, Igarashi Y. ÔThe leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.Õ FEBS Lett. 2005 Aug 15;579(20):4383-8.
-
Protein numbersee ncbi
-
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
TestYou can block the antibody by the specific target amino acid sequence of peptide.
-
Propertiesblocking peptide
-
DescriptionPeptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
-
Gene target
-
Gene symbolS1PR3, S1PR5, S1PR1, LPAR2, MIR1302-3, MIR509-3, MIR7-3, PIRC13
-
Short nameSphingosine 1 Phosphate 3 Receptor (EDG-3) CT - Blocking Peptide
-
Techniqueblocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
-
Isotypenot specified
-
Labelunlabeled
-
Alternative nameSphingosine 1 Phosphate 3 Receptor (EDG-3) CT - inhibiting short protein sequence
-
Alternative techniquecontrol, peptides
-
Gene info
-
Identity
-
Gene
-
Long gene namesphingosine-1-phosphate receptor 3
-
Synonyms gene
-
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
- chromosome 9 open reading frame 47
- chromosome 9 open reading frame 108
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-05-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Sphingosine 1-phosphate receptors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesphingosine-1-phosphate receptor 5
-
Synonyms gene
-
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-01-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Sphingosine 1-phosphate receptors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesphingosine-1-phosphate receptor 1
-
Synonyms gene
-
Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-05-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Sphingosine 1-phosphate receptors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namelysophosphatidic acid receptor 2
-
Synonyms gene
-
Synonyms gene name
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-02-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Lysophosphatidic acid receptors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1302-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1302 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 509-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR506 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 7-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR7 family
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 13
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
