Sheep anti Vesicle Associated Membrane Protein (VAMP 1/2)

• Catalog number
  K105P
• Price
  Please ask
• Size
  250 μg

• Category
  Primary Antibodies
• Long description
  Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
• Antibody come from
  Full length VAMP1/2 protein
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Sheep anti Vesicle Associated Membrane Protein (VAMP 1/2) Antibody
• Antibody is raised in
  Sheep
• Antibody s reacts with
  Human, Rat
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot, Immunoprecipitation,
• Antibody s suited for
  Applications: Western Blotting, Immunoprecipitation
• Storage
  -20ºC
• Relevant references
  1. Moreno, J.A., et al. Sustained translational repression by eIF2 -P mediates prion neurodegeneration. Nature (2012), 485, 507-511
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. 

• Gene target
  Vesicle   Associated   Membrane   Protein   VAMP   1/2  
• Gene symbol
  VAMP7, VAMP8, VAMP1, VAMP2
• Short name
  anti Vesicle Associated Protein (VAMP 1/2)
• Technique
  anti, antibody to
• Host
  Sheep
• Isotype
  not specified
• Label
  unlabeled
• Species
  Sheep, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
• Alternative name
  ovine antibody to Vesicle Associated Membrane Protein (VAMP 1/2)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11486
• Gene
  VAMP7
• Long gene name
  vesicle associated membrane protein 7
• Synonyms gene
  • SYBL1
• Synonyms gene name
  • synaptobrevin-like 1
• Synonyms
  • VAMP-7
  • TI-VAMP
• GenBank acession
  • AJ295938
• Locus
  Xq28 and Yq12
• Discovery year
  1996-06-21
• Entrez gene record
  6845
• Pubmed identfication
  • 8640232
  • 11440841
• RefSeq identity
  • NM_005638
• Classification
  • Pseudoautosomal region 2
  • Vesicle associated membrane proteins
• VEGA ID
  OTTHUMG00000022679
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:12647
• Gene
  VAMP8
• Long gene name
  vesicle associated membrane protein 8
• Synonyms
  • EDB
  • VAMP-8
• Synonyms name
  • endobrevin
• GenBank acession
  • AF053233
• Locus
  2p11.2
• Discovery year
  1998-11-30
• Entrez gene record
  8673
• Pubmed identfication
  • 9878266
  • 9614193
• RefSeq identity
  • NM_003761
• Classification
  • Vesicle associated membrane proteins
• VEGA ID
  OTTHUMG00000130180

Gene info

• Identity
  HGNC:12642
• Gene
  VAMP1
• Long gene name
  vesicle associated membrane protein 1
• Synonyms gene
  • SYB1
• Synonyms gene name
  • synaptobrevin 1
• Synonyms
  • VAMP-1
• Locus
  12p13.31
• Discovery year
  1990-03-14
• Entrez gene record
  6843
• Pubmed identfication
  • 1976629
• Classification
  • Vesicle associated membrane proteins
• VEGA ID
  OTTHUMG00000168269

Gene info

• Identity
  HGNC:12643
• Gene
  VAMP2
• Long gene name
  vesicle associated membrane protein 2
• Synonyms gene
  • SYB2
• Synonyms gene name
  • synaptobrevin 2
• Synonyms
  • VAMP-2
• Locus
  17p13.1
• Discovery year
  1990-03-14
• Entrez gene record
  6844
• Pubmed identfication
  • 1976629
• Classification
  • Vesicle associated membrane proteins
• VEGA ID
  OTTHUMG00000150254

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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