Sheep anti ELK rec tyr Kinase (Eph B1 SAM.)
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Catalog numberS105P
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PricePlease ask
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Size250 μg
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CategoryPrimary Antibodies
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Long descriptionThe immunogen used for the anti-human ephB1 (Elk receptor) -SAM region was a GST fusion protein ephB1 (Elk receptor) -SAM corresponding to amino acid sequence 883-984 of the C terminus region and having a molecular weight of 116 kD. ephB1, previously known as Elk (eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
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Antibody come fromA GST fusion protein ephB1 (Elk receptor) -SAM corresponding to amino acid sequence 883-984 of the C terminus region and having a molecular weight of 116 kD
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
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ClonePolyclonal
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Antigen antibody binding interactionSheep anti ELK rec tyr Kinase (Eph B1 SAM.) Antibody
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Antibody is raised inSheep
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Antibody s reacts withHuman
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationImmunoprecipitation
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Antibody s suited forApplications: 1-10 ug/ml for Western Blotting and 10-20 ug/ml for Immunoprecipitation.
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Storage-20ºC
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Relevant references1. Stein, E., et al. 'Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.' J. Biol. Chem., 273, 1303-1308 (1998)_x000B__x000B_2. Han, D.C., et al. 'EphB1 associates with Grb7 and regulates cell migration.' J. Biol. Chem., 277, 45655-45661 (2002)_x000B__x000B_3. Vindis, C., et al. 'EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.' J. Cell Biol., 162, 661-671 (2003)
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Gene target
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Gene symbolEFNB1, FGFR2, FGFR1
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Short nameanti ELK rec tyr Kinase (Eph B1 SAM.)
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Techniqueanti, antibody to
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HostSheep
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Isotypenot specified
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Labelunlabeled
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SpeciesElk, Elks, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
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Alternative nameovine antibody to ELK rec L-tyrosine phosphorylation catalyst (Eph B1 SAM.)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameephrin B1
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Synonyms gene
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Synonyms gene name
- craniofrontonasal syndrome (craniofrontonasal dysplasia)
- ephrin-B1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-01-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ephrins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namefibroblast growth factor receptor 2
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Synonyms gene
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Synonyms gene name
- bacteria-expressed kinase
- keratinocyte growth factor receptor
- craniofacial dysostosis 1
- Jackson-Weiss syndrome
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-05-09
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Entrez gene record
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RefSeq identity
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Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namefibroblast growth factor receptor 1
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Synonyms gene
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Synonyms gene name
- fms-related tyrosine kinase 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-02-25
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Entrez gene record
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Pubmed identfication
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Classification
- I-set domain containing
- Receptor tyrosine kinases
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
