Rabbit anti Toll-like receptor 6 (TLR6) (IN)
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Catalog number
X1815P
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Price
Please ask
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Size
100 μg
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Category
Primary Antibodies
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Long description
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6)
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Antibody come from
Rabbit polyclonal UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A.
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Other description
Provided as solution in phosphate buffered saline with 0.02% sodium azide. Antigen Immunoaffiinity Purification
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti Toll-like receptor 6 (TLR6) (IN) Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Human
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot
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Antibody s suited for
UEV1A antibody can be used for detection of UEV1A by Western blot at 1 to 2 ug/ml. Anti-UEV1A may also recognize other isoforms of UEV1A.
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Storage
-20ºC
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Relevant references
1) Sancho E, Vila MR, Sanchez-Pulido L, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.Mol. Cell Biol. 1998; 18:576-89._x000B_2) Akira S and Takeda K. Toll-like receptor Signalling.Nat. Rev. Immunol. 2004; 4:499-511_x000B_3) Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.Mol. Interv. 2003; 3:466-77_x000B_4) Deng L, Wang C, Spencer E, et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103:351-61._x000B_5) Wang C, Deng L, Hong M, et al. TAK1 is a ubiquitindependent kinase of MKK and IKK. Nature 2001; 412:346-51. _x000B_6) Yamaguchi K, Shirakabe K, Shibuya H, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF- signal transduction. Science 1995; 270:2008-11. _x000B_7) Alternative product of entry: Q13404, more Accessed Febraury 27, 2007
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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Gene target
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Gene symbol
TLR6
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Short name
Rabbit anti Toll-like receptor 6 (TLR6) (IN)
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Technique
Rabbit, anti, antibody to
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Host
Rabbit, Rabbits
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Isotype
not specified
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Label
unlabeled
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Alternative name
production species: rabbit antibody to Toll-like receptor 6 (toll-like receptor 6) (IN)
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Alternative technique
rabbit-anti, antibodies
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Alternative to gene target
toll-like receptor 6, CD286, TLR6 and IDBG-13675 and ENSG00000174130 and 10333, lipopeptide binding, Plasma membranes, Tlr6 and IDBG-165921 and ENSMUSG00000051498 and 21899, BT.45021 and IDBG-641606 and ENSBTAG00000014031 and 407237
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Gene info
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Identity
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Gene
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Long gene name
toll like receptor 6
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Synonyms gene name
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Synonyms
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Locus
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Discovery year
2001-10-01
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Entrez gene record
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Pubmed identfication
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Classification
- Toll like receptors
- CD molecules
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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