Rabbit anti Sphingomyelin Phosphodiesterase 3

• Catalog number
  X2360P
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.
• Antibody come from
  Synthetic peptide derived from human CERTL protein
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Sphingomyelin Phosphodiesterase 3 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western blot
• Antibody s suited for
  For use with CERTL polyclonal antibodies (Cat. No. X2089P & X2379P).
• Storage
  -80ºC
• Relevant references
  1. Hanada K., Kumagai K., Yasuda S., Miura Y., Kawano M., Fukasawa M., Nishijima M.;_x000B_Molecular machinery for non-vesicular trafficking of ceramide.; Nature 426:803-809(2003)._x000B_2. Raya A., Revert F., Navarro S., Saus J.; Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen.; J. Biol. Chem. 274:12642-12649(1999)._x000B_3. Raya A., Revert-Ros F., Martinez-Martinez P., Navarro S., Rosello E., Vieites B., Granero F., Forteza J., Saus J.; Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis.; J. Biol. Chem. 275:40392-40399(2000)._x000B_4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004)._x000B_5. Ogi T., Yamamoto Y., Ohmori H.; Homo sapiens genomic sequence, containing DINB1 and GPBP gene.; Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases._x000B_6. Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.; Cell 127:635-648(2006).
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  Sphingomyelin   Phosphodiesterase  
• Gene symbol
  SMPD4, SMPD3, SMPD4P2
• Short name
  Rabbit anti Sphingomyelin Phosphodiesterase 3
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Sphingomyelin Phosphodiesterase 3
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:32949
• Gene
  SMPD4
• Long gene name
  sphingomyelin phosphodiesterase 4
• Synonyms gene name
  • sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
• Synonyms
  • FLJ20297
  • FLJ20756
  • nSMase-3
  • KIAA1418
  • NSMASE3
  • NET13
• Synonyms name
  • neutral sphingomyelinase-3
• GenBank acession
  • AF052134
• Locus
  2q21.1
• Discovery year
  2006-07-12
• Entrez gene record
  55627
• Pubmed identfication
  • 16517606
• RefSeq identity
  • NM_017751
• VEGA ID
  OTTHUMG00000131624

Gene info

• Identity
  HGNC:14240
• Gene
  SMPD3
• Long gene name
  sphingomyelin phosphodiesterase 3
• Synonyms gene name
  • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
• Synonyms
  • NSMASE2
• Synonyms name
  • neutral sphingomyelinase II
• GenBank acession
  • AJ250460
• Locus
  16q22.1
• Discovery year
  2000-12-12
• Entrez gene record
  55512
• Pubmed identfication
  • 10823942
• RefSeq identity
  • NM_018667
• VEGA ID
  OTTHUMG00000137559

Gene info

• Identity
  HGNC:39674
• Gene
  SMPD4P2
• Long gene name
  sphingomyelin phosphodiesterase 4 pseudogene 2
• Synonyms gene name
  • sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene 2
• Locus
  13q12.11
• Discovery year
  2011-03-22
• Entrez gene record
  441654
• RefSeq identity
  • NG_011395
• VEGA ID
  OTTHUMG00000016483

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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