Rabbit anti Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody NARC1

• Catalog number
  X2665P
• Price
  Please ask
• Size
  10MinibLots

• Category
  Primary Antibodies
• Long description
  PCSK9 binds to the EGF-A domain of the LDLR and signals LDLR degradation. Reduced LDLR levels result in decreased LDL (low density lipid) metabolism leading to hypercholesterolemia. _x000B__x000B_Additioanlly, PCSK9 may be implicated in the differentiation of cortical neurons and may also play a role in cholesterol homeostasis. Defects in PCSK9 gene are the cause of familial hypercholesterolemia 3 (FH3). The protein is thought to play a central role in cholesterol homeostais. For an antibody that targets the blocking epitope of the PCSK-LDLR interaction use X2404P.
• Antibody come from
  Synthetic peptide derived from the rat alpha1E calcium channel conjugated to KLH
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffiinity Purification
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody NARC1 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot, ELISA
• Antibody s suited for
  Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Soong,T.W et al. 'Structure and functional expression of a member of the low voltage-activated calcium channel family' Science 260 (5111), 1133-1136 (1993)_x000B__x000B_2. Chen, S. et al. 'Alpha 1E subunit of the R-type calcium channel is associated with myelinogenesis.' J. Neurocytol. 29(10), 719-28 (2000)
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  Proprotein   convertase   subtilisin/kexin   PCSK9   NARC1  
• Gene symbol
  PCSK9
• Short name
  Rabbit anti Proprotein convertase subtilisin/kexin 9 (PCSK9) antibody NARC1
• Technique
  Antibody, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Proprotein convertase subtilisin/kexin classification 9 (proprotein convertase subtilisin/kexin classification 9) (antibody to-) NARC1
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  proprotein convertase subtilisin/kexin type 9, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, very-low-density lipoprotein particle receptor binding, Extracellular, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102

Gene info

• Identity
  HGNC:20001
• Gene
  PCSK9
• Long gene name
  proprotein convertase subtilisin/kexin type 9
• Synonyms gene
  • HCHOLA3
• Synonyms gene name
  • hypercholesterolemia, autosomal dominant 3
• Synonyms
  • NARC-1
  • FH3
• GenBank acession
  • AX207686
• Locus
  1p32.3
• Discovery year
  2003-05-13
• Entrez gene record
  255738
• Pubmed identfication
  • 12552133
  • 12730697
• RefSeq identity
  • NM_174936
• Classification
  • Proprotein convertase subtilisin/kexin family
• VEGA ID
  OTTHUMG00000008136
• Locus Specific Databases
  • British Heart Foundation
  • LRG_275

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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