Rabbit anti Lysophosphatidic Acid Receptor 1 CT (EDG-2)

• Catalog number
  C174P
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
• Antibody come from
  Synthetic peptide derived from the C terminal of the EDG2 receptor.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Lysophosphatidic Acid Receptor 1 CT (EDG-2) Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  For Western blotting, starting dilution of 5-10 µg/ml is recommended. Western blot should be visualized using a high sensitivity secondary/substrate system (i.e. PierceÕs SuperSignal West Femto Maximum Sensitivity Substrate). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Fukushima, N., et al., 'A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl.Acad. Sci. USA 1998, 95, 6151-6156_x000B__x000B_2. Goetzl, E., et al., 'Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.' J. Immunol. 1999, 162, 2049-2056_x000B__x000B_3. Zheng, Y., et al. 'Lysophosphatidic acid receptor-selection effects on Jurkat T cell migration through a matrigel model basement membrane.' J. Immunol. 2001, 166, 2317-2322_x000B__x000B_4. Parrill, A.L., et al. 'Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.' J. Biol. Chem. 2000, 275, 39379-39384.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  Lysophosphatidic   Acid   Receptor   EDG-2  
• Gene symbol
  BUD31, LPAR1, S1PR5, S1PR1, LPAR2, S1PR3, LPAR3, MIR1289-2, MIR521-2, MIR509-2
• Short name
  Rabbit anti Lysophosphatidic Acid Receptor 1 CT (EDG-2)
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Lysophosphatidic Acid Receptor 1 CT (EDG-2)
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:29629
• Gene
  BUD31
• Long gene name
  BUD31 homolog
• Synonyms gene
  • G10
• Synonyms gene name
  • G10 maternal transcript homolog (Xenopus laevis)
  • BUD31 homolog (yeast)
  • BUD31 homolog (S. cerevisiae)
• Synonyms
  • YCR063W
  • EDG-2
  • EDG2
  • fSAP17
  • Cwc14
• Synonyms name
  • functional spliceosome-associated protein 17
• GenBank acession
  • BC022821
• Locus
  7q22.1
• Discovery year
  2006-03-10
• Entrez gene record
  8896
• Pubmed identfication
  • 7841202
• RefSeq identity
  • NM_003910
• Classification
  • Spliceosomal C complex
  • NTC associated proteins
  • Spliceosomal B complex
  • Spliceosomal Bact complex
  • Spliceosomal P complex
• VEGA ID
  OTTHUMG00000154602

Gene info

• Identity
  HGNC:3166
• Gene
  LPAR1
• Long gene name
  lysophosphatidic acid receptor 1
• Synonyms gene
  • EDG2
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
• Synonyms
  • edg-2
  • rec.1.3
  • vzg-1
  • Gpcr26
  • Mrec1.3
  • LPA1
• GenBank acession
  • U80811
• Locus
  9q31.3
• Discovery year
  1998-05-15
• Entrez gene record
  1902
• Pubmed identfication
  • 8922387
  • 9070858
• RefSeq identity
  • NM_057159
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000020486

Gene info

• Identity
  HGNC:14299
• Gene
  S1PR5
• Long gene name
  sphingosine-1-phosphate receptor 5
• Synonyms gene
  • EDG8
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
• Synonyms
  • Edg-8
• GenBank acession
  • AK074661
• Locus
  19p13.2
• Discovery year
  2001-01-02
• Entrez gene record
  53637
• Pubmed identfication
  • 10799507
• RefSeq identity
  • NM_030760
• Classification
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000180581

Gene info

• Identity
  HGNC:3165
• Gene
  S1PR1
• Long gene name
  sphingosine-1-phosphate receptor 1
• Synonyms gene
  • EDG1
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
• Synonyms
  • edg-1
  • D1S3362
  • CD363
• GenBank acession
  • M31210
• Locus
  1p21.2
• Discovery year
  1998-05-15
• Entrez gene record
  1901
• Pubmed identfication
  • 2160972
  • 9488656
• RefSeq identity
  • NM_001400
• Classification
  • CD molecules
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000010835

Gene info

• Identity
  HGNC:3168
• Gene
  LPAR2
• Long gene name
  lysophosphatidic acid receptor 2
• Synonyms gene
  • EDG4
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
• Synonyms
  • EDG-4
  • LPA2
• GenBank acession
  • AF011466
• Locus
  19p13.11
• Discovery year
  1999-02-15
• Entrez gene record
  9170
• Pubmed identfication
  • 9525886
  • 9804623
• RefSeq identity
  • NM_004720
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000182328

Gene info

• Identity
  HGNC:3167
• Gene
  S1PR3
• Long gene name
  sphingosine-1-phosphate receptor 3
• Synonyms gene
  • EDG3
  • C9orf47
  • C9orf108
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
  • chromosome 9 open reading frame 47
  • chromosome 9 open reading frame 108
• Synonyms
  • EDG-3
  • FLJ37523
  • bA791O21.3
• Synonyms name
  • sphingosine-1-phosphate receptor 3
• GenBank acession
  • AF022139
• Locus
  9q22.1
• Discovery year
  1998-05-15
• Entrez gene record
  1903
• Pubmed identfication
  • 8878560
  • 9409733
• RefSeq identity
  • NM_005226
• Classification
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000020173

Gene info

• Identity
  HGNC:14298
• Gene
  LPAR3
• Long gene name
  lysophosphatidic acid receptor 3
• Synonyms gene
  • EDG7
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
• Synonyms
  • LP-A3
  • Edg-7
  • RP4-678I3
  • HOFNH30
  • LPA3
• GenBank acession
  • AF127138
• Locus
  1p22.3
• Discovery year
  2001-01-02
• Entrez gene record
  23566
• Pubmed identfication
  • 10488122
• RefSeq identity
  • NM_012152
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000009925

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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