Rabbit anti LNX1

• Catalog number
  X2340P
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65
• Antibody come from
  Synthetic peptide derived from human DEGS2 protein.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti LNX1 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western blot
• Antibody s suited for
  Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -80ºC
• Relevant references
  1. Mizutani, Y., et al. 'Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.; FEBS Lett. 563:93-97(2004)._x000B__x000B_2. Omae, F., et al. 'DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.' Biochem J. 2004 May 1;379(Pt 3):687-95._x000B__x000B_3. Omae, F. et al. 'Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2.' FEBS Lett. 2004 Oct 8;576(1-2):63-7. _x000B__x000B_4. Enomoto, A., et al. 'Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.' Biochem J. 2006 Jul 15;397(2):289-95.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  LNX1  
• Gene symbol
  LNX1-AS2, LNX1-AS1, LNX1
• Short name
  Rabbit anti LNX1
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to LNX1
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:41450
• Gene
  LNX1-AS2
• Long gene name
  LNX1 antisense RNA 2
• Synonyms gene name
  • LNX1 antisense RNA 2 (non-protein coding)
• Locus
  4q12
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000160646

Gene info

• Identity
  HGNC:40345
• Gene
  LNX1-AS1
• Long gene name
  LNX1 antisense RNA 1
• Synonyms gene name
  • LNX1 antisense RNA 1 (non-protein coding)
• Locus
  4q12
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000160644

Gene info

• Identity
  HGNC:6657
• Gene
  LNX1
• Long gene name
  ligand of numb-protein X 1
• Synonyms gene
  • LNX
• Synonyms gene name
  • ligand of numb-protein X
  • ligand of numb-protein X 1, E3 ubiquitin protein ligase
• Synonyms
  • MPDZ
  • PDZRN2
• GenBank acession
  • AF237782
• Locus
  4q12
• Discovery year
  2000-05-31
• Entrez gene record
  84708
• Pubmed identfication
  • 11521506
  • 11782429
• Classification
  • Ring finger proteins
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000102099

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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