Rabbit anti GFR a-2 (IN)
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Catalog numberX1792P
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionMembers of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRα, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRα was also termed GDNFRβ, Ret ligand 2 (RETL2) or TGFβ-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα-2 recently. GFRα-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRα-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
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Antibody come fromRabbit polyclonal TIRP antibody was raised against a peptide corresponding to amino acids at the C-terminus of human TIRP.
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Other descriptionAntigen Immunoaffiinity Purification
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ClonePolyclonal
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Antigen antibody binding interactionRabbit anti GFR a-2 (IN) Antibody
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Antibody is raised inRabbit
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Antibody s reacts withHuman, Mouse, Rat
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationWestern Blot
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Antibody s suited forTIRP (CT) antibody can be used for detection of TIRP by Western blot at 0.5 to 2 μg/ml.
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Storage-20ºC
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Relevant references_x000B_1) OÕNeill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003;24:286-9._x000B_2 ) Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003;3:466-77._x000B_3 ) Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335-76._x000B_4 ) Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002;20:197-216._x000B_5) UniProtKB/TrEMBL entry Q86XR7, more Accessed January 30, 2007
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolRAPGEF5, GFRA1
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Short nameRabbit anti GFR a-2 (IN)
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TechniqueRabbit, anti, antibody to
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HostRabbit, Rabbits
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Isotypenot specified
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Labelunlabeled
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Alternative nameproduction species: rabbit antibody to GFR a-2 (IN)
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Alternative techniquerabbit-anti, antibodies
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Gene info
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Identity
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Gene
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Long gene nameRap guanine nucleotide exchange factor 5
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Synonyms gene name
- Rap guanine nucleotide exchange factor (GEF) 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-03-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameGDNF family receptor alpha 1
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-01-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data