Rabbit anti Aprataxin
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Catalog numberX2411P
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionDNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Protein is widely expressed. Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome, an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy. Also a cause of coenzyme Q10 deficiency. Coenzyme Q10 deficiency is an autosomal recessive disorder with variable manifestations. It can be associated with three main clinical phenotypes: a predominantly myopathic form with central nervous system involvement, an infantile encephalomyopathy with renal dysfunction and an ataxic form with cerebellar atrophy. Coenzyme Q10 deficiency due to APTX mutations is typically associated with cerebellar ataxia.
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Antibody come fromInfluenza A, strain USSR, H1N1, purified virons.
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Other descriptionSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide before the addition of 40% glycerol. Labeled with Biotin. Ammonium Sulfate Precipitation
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ClonePolyclonal
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Antigen antibody binding interactionRabbit anti Aprataxin Antibody
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Antibody is raised inRabbit
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Antibody s reacts withHuman, Rat, Mouse
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationWestern blotting, ELISA
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Antibody s suited forOptimal concentration should be evaluated by serial dilutions._x000B_
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Storage-80ºC
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Relevant referencesno information yet
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolAPTX, APLF
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Short nameRabbit anti Aprataxin
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TechniqueRabbit, anti, antibody to
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HostRabbit, Rabbits
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Isotypenot specified
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Labelunlabeled
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Alternative nameproduction species: rabbit antibody to Aprataxin
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Alternative techniquerabbit-anti, antibodies
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Gene info
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Identity
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Gene
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Long gene nameaprataxin
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Synonyms gene
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Synonyms gene name
- ataxia 1, early onset with hypoalbuminemia
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histidine triad superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameaprataxin and PNKP like factor
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Synonyms gene
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Synonyms gene name
- chromosome 2 open reading frame 13
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-01-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
