Mouse anti SPARC

• Catalog number
  X2546M
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer._x000B__x000B_SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).
• Antibody come from
  Influenza A/Puerto Rico/8/34 (H1N1) and A/Bangkok/ 1/ 79 (H3N2) viruses.
• Other description
  Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. Protein A/G Chromatography
• Clone
  LM2
• Antigen antibody binding interaction
  Mouse anti SPARC Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Immunohistochemistry (Paraffin Tissues), Flow Cytometry, Western Blotting
• Antibody s suited for
  Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  no information yet
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  SPARC  
• Gene symbol
  CLMAT3, SPARC
• Short name
  Mouse anti SPARC
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG1
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to secreted protein, acidic, cysteine-rich (osteonectin)
• Alternative technique
  murine, antibodies
• Alternative to gene target
  secreted protein, acidic, cysteine-rich (osteonectin), ON, SPARC and IDBG-54562 and ENSG00000113140 and 6678, extracellular matrix binding, nuclei, Sparc and IDBG-175174 and ENSMUSG00000018593 and 20692, SPARC and IDBG-646341 and ENSBTAG00000014835 and 282077

Gene info

• Identity
  HGNC:52287
• Gene
  CLMAT3
• Long gene name
  colorectal liver metastasis associated transcript 3
• Synonyms
  • SPARC-AS1
• Synonyms name
  • SPARC antisense RNA 1
• Locus
  5q33.1
• Discovery year
  2017-06-15
• Entrez gene record
  101927096
• Pubmed identfication
  • 26050227
• RefSeq identity
  • NR_109873
• Classification
  • Long non-coding RNAs with non-systematic symbols

Gene info

• Identity
  HGNC:11219
• Gene
  SPARC
• Long gene name
  secreted protein acidic and cysteine rich
• Synonyms gene
  • ON
• Synonyms gene name
  • osteonectin
• Synonyms
  • ONT
  • BM-40
• Synonyms name
  • cysteine-rich protein
  • secreted protein acidic and rich in cysteine
• Locus
  5q33.1
• Discovery year
  2001-06-22
• Entrez gene record
  6678
• Pubmed identfication
  • 2838412
  • 3410046
• RefSeq identity
  • NM_003118
• Classification
  • SPARC family
• VEGA ID
  OTTHUMG00000130122

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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