Mouse anti Sodium Calcium Exchanger 1

• Catalog number
  X1685M
• Price
  Please ask
• Size
  10MinibLots

• Category
  Primary Antibodies
• Long description
  Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
• Antibody come from
  Full-length recombinant sphingomyelin synthase r fusion protein
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
• Clone
  6H2
• Antigen antibody binding interaction
  Mouse anti Sodium Calcium Exchanger 1 Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Rabbit
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  Antibody can be used for Western blotting (5-10µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -80ºC
• Relevant references
  1. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33-44. Epub 2003 Dec 18.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Sodium   Calcium   Exchanger  
• Gene symbol
  SLC8A1, SLC24A1, SLC25A3P1
• Short name
  Mouse anti Sodium Calcium Exchanger 1
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG2b
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to Sodium Calcium Exchanger 1
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:11068
• Gene
  SLC8A1
• Long gene name
  solute carrier family 8 member A1
• Synonyms gene
  • NCX1
• Synonyms gene name
  • solute carrier family 8 (sodium/calcium exchanger), member 1
• Synonyms name
  • Na+/Ca++ exchanger
• Locus
  2p22.1
• Discovery year
  1991-10-04
• Entrez gene record
  6546
• Pubmed identfication
  • 1559714
• RefSeq identity
  • NM_021097
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000102183

Gene info

• Identity
  HGNC:10975
• Gene
  SLC24A1
• Long gene name
  solute carrier family 24 member 1
• Synonyms gene name
  • solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
• Synonyms
  • NCKX1
  • NCKX
  • RODX
  • KIAA0702
  • HsT17412
  • CSNB1D
• GenBank acession
  • AF062922
• Locus
  15q22.31
• Discovery year
  1999-02-18
• Entrez gene record
  9187
• Pubmed identfication
  • 9856482
• RefSeq identity
  • NM_004727
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000167960

Gene info

• Identity
  HGNC:26869
• Gene
  SLC25A3P1
• Long gene name
  solute carrier family 25 member 3 pseudogene 1
• Synonyms gene name
  • solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 pseudogene 1
  • solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 pseudogene 1
• Synonyms
  • FLJ40434
• Locus
  1p32.3
• Discovery year
  2012-03-02
• Entrez gene record
  163742
• RefSeq identity
  • NR_002314
• VEGA ID
  OTTHUMG00000008078

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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