Mouse anti Keratin 18
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Catalog numberX1254M
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionCytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification._x000B__x000B_CK18 is an acidic keratin which is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. CK18 exists in combination with CK8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only cytokeratins 8 and 18.
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Antibody come fromn/a
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Other descriptionProtein A/G Chromatography
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CloneDC10
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Antigen antibody binding interactionMouse anti Keratin 18 Antibody
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Antibody is raised inMouse
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Antibody s reacts withHuman
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationWestern Blot, Immunohistochemistry (Frozen & Paraffin Sections)
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Antibody s suited forOptimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant referencesno information yet
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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Gene target
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Gene symbolKRT18P13, KRT18, KRT18P15
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Short nameMouse anti Keratin 18
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TechniqueMouse, anti, antibody to, mouses
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Hostmouse
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IsotypeIgG1
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Labelunlabeled
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SpeciesMouse, Mouses
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Alternative nameMouse antibody to Keratin 18
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Alternative techniquemurine, antibodies
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Gene info
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Identity
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Gene
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Long gene namekeratin 18 pseudogene 13
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Synonyms gene
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Synonyms gene name
- keratin 18-like 3
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Locus
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Discovery year1989-05-11
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekeratin 18
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Synonyms gene name
- keratin 18, type I
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Locus
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Discovery year1988-08-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Keratins, type I
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekeratin 18 pseudogene 15
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Synonyms gene
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Synonyms gene name
- keratin 18-like 5
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Locus
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Discovery year2006-01-09
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data