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Category
Primary Antibodies
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Long description
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA Polymerase II. There are approximately 20 known hnRNP proteins, which range in size from 34 kDa to 120 kDa, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm, such as hnRNP K. hnRNP K, a 65 kDa protein, recruits a variety of molecular partners through two K homologous (KH) domains, which are required for protein-protein interactions. hnRNP K also contains several potential phosphorylation sites, including Ser 302, the major site of PKCd phosphorylation, which are thought to regulate various cellular functions, including sequence-specific DNA binding, transcription, RNA binding and nucleocytoplasmic shuttling.
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Antibody come from
A synthetic peptide to the N-terminal domain of human CCR10, linked to KLH
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Other description
Phosphate buffered saline containing 0.1% sodium azide. Protein A/G Chromatography
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Clone
F45 P9 C7
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Antigen antibody binding interaction
Mouse anti Heterogeneous Nuclear Ribonucleoprotein K Antibody
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Antibody is raised in
Mouse
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Antibody s reacts with
Human, Mouse, Rat, Rabbit, Chicken
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot, Immunohistochemistry
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Antibody s suited for
Optimal concentration should be evaluated by serial dilutions.( WrkConcMin: 5 µg/ml)
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Storage
-80ºC
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Relevant references
1. Bonini, J.A., et al 'Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.' DNA Cell Biol 1997, 16, 1249-1256_x000B__x000B_2. Xiong, N., et al. 'CCR10 and its ligands in regulation of epithelial immunity and diseases.' Protein Cell 2012, epub_x000B__x000B_3. Mirshahpanah, P., et al. 'CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity.' Exp. Dermatol. 2008, 17, 30-34
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
