Lysophosphatidic Acid Receptor 1 CT (EDG-2) - Blocking Peptide

• Catalog number
  X1269B
• Price
  Please ask
• Size
  50 μg

• Category
  Proteins & Peptides
• Long description
  Endothelial cell differentiation gene-2 (EDG2), or LPA1, receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG2 (LPA1) is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
• Antibody come from
  n/a
• Other description
  No other information available
• Clone
  not specified
• Antigen antibody binding interaction
  Lysophosphatidic Acid Receptor 1 CT (EDG-2) - Blocking Peptide
• Antibody is raised in
  N/A
• Antibody s reacts with
  see techfile
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Antibody function blocking
• Antibody s suited for
  1. 2-20 µl, 20-200 µl and 200-1000 µl precision pipetters with disposable tips_x000B_2. Wash bottle or multichannel dispenser for washing_x000B_3. 2000 ml graduated cylinder_x000B_4. PBS (137 mM NaCl, 2.7 mM KCl, 4.3 mM Na2HPO4-7H2O, 1.4 mM_x000B_KH2PO4)_x000B_5. Deionized or distilled H2O_x000B_6. Spectrophotometer capable of measuring absorbance in 96-well plates using_x000B_dual wavelength of 450-540 or 450-595 nm or a single read at 450 nm._x000B_7. Tissue culture microtiter plate (96 well culture dish)_x000B_8. Sterile reagent troughs_x000B_9. Micro syringe filter (0.2 µm)_x000B_10. Syringe
• Storage
  -20ºC
• Relevant references
  1. Hawker JR Jr., 'Chemiluminescence-based BrdU ELISA to measure DNA synthesis.' J Immunol Methods. 2003 Mar 1;274(1-2):77-82._x000B__x000B_2. Ang, L.P.K., et al. 'Development of a conjunctival epithelial equivalent with improved proliferative properties using a multistep serum-free culture system.' Investigative Ophthalmology & Visual Science, 2004, 45, 1789-1795
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Test
  You can block the antibody by the specific target amino acid sequence of peptide.
• Properties
  blocking peptide
• Description
  Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Lysophosphatidic   Acid   Receptor   EDG-2  
• Gene symbol
  BUD31, LPAR1, S1PR5, S1PR1, LPAR2, S1PR3, LPAR3, MIR7-2, MIR329-2, MIR512-2
• Short name
  Lysophosphatidic Acid Receptor 1 CT (EDG-2) - Blocking Peptide
• Technique
  blocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
• Isotype
  N/A
• Label
  unlabeled
• Alternative name
  Lysophosphatidic Acid Receptor 1 CT (EDG-2) - inhibiting short protein sequence
• Alternative technique
  control, peptides

Gene info

• Identity
  HGNC:29629
• Gene
  BUD31
• Long gene name
  BUD31 homolog
• Synonyms gene
  • G10
• Synonyms gene name
  • G10 maternal transcript homolog (Xenopus laevis)
  • BUD31 homolog (yeast)
  • BUD31 homolog (S. cerevisiae)
• Synonyms
  • YCR063W
  • EDG-2
  • EDG2
  • fSAP17
  • Cwc14
• Synonyms name
  • functional spliceosome-associated protein 17
• GenBank acession
  • BC022821
• Locus
  7q22.1
• Discovery year
  2006-03-10
• Entrez gene record
  8896
• Pubmed identfication
  • 7841202
• RefSeq identity
  • NM_003910
• Classification
  • Spliceosomal C complex
  • NTC associated proteins
  • Spliceosomal B complex
  • Spliceosomal Bact complex
  • Spliceosomal P complex
• VEGA ID
  OTTHUMG00000154602

Gene info

• Identity
  HGNC:3166
• Gene
  LPAR1
• Long gene name
  lysophosphatidic acid receptor 1
• Synonyms gene
  • EDG2
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
• Synonyms
  • edg-2
  • rec.1.3
  • vzg-1
  • Gpcr26
  • Mrec1.3
  • LPA1
• GenBank acession
  • U80811
• Locus
  9q31.3
• Discovery year
  1998-05-15
• Entrez gene record
  1902
• Pubmed identfication
  • 8922387
  • 9070858
• RefSeq identity
  • NM_057159
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000020486

Gene info

• Identity
  HGNC:14299
• Gene
  S1PR5
• Long gene name
  sphingosine-1-phosphate receptor 5
• Synonyms gene
  • EDG8
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
• Synonyms
  • Edg-8
• GenBank acession
  • AK074661
• Locus
  19p13.2
• Discovery year
  2001-01-02
• Entrez gene record
  53637
• Pubmed identfication
  • 10799507
• RefSeq identity
  • NM_030760
• Classification
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000180581

Gene info

• Identity
  HGNC:3165
• Gene
  S1PR1
• Long gene name
  sphingosine-1-phosphate receptor 1
• Synonyms gene
  • EDG1
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
• Synonyms
  • edg-1
  • D1S3362
  • CD363
• GenBank acession
  • M31210
• Locus
  1p21.2
• Discovery year
  1998-05-15
• Entrez gene record
  1901
• Pubmed identfication
  • 2160972
  • 9488656
• RefSeq identity
  • NM_001400
• Classification
  • CD molecules
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000010835

Gene info

• Identity
  HGNC:3168
• Gene
  LPAR2
• Long gene name
  lysophosphatidic acid receptor 2
• Synonyms gene
  • EDG4
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
• Synonyms
  • EDG-4
  • LPA2
• GenBank acession
  • AF011466
• Locus
  19p13.11
• Discovery year
  1999-02-15
• Entrez gene record
  9170
• Pubmed identfication
  • 9525886
  • 9804623
• RefSeq identity
  • NM_004720
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000182328

Gene info

• Identity
  HGNC:3167
• Gene
  S1PR3
• Long gene name
  sphingosine-1-phosphate receptor 3
• Synonyms gene
  • EDG3
  • C9orf47
  • C9orf108
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
  • chromosome 9 open reading frame 47
  • chromosome 9 open reading frame 108
• Synonyms
  • EDG-3
  • FLJ37523
  • bA791O21.3
• Synonyms name
  • sphingosine-1-phosphate receptor 3
• GenBank acession
  • AF022139
• Locus
  9q22.1
• Discovery year
  1998-05-15
• Entrez gene record
  1903
• Pubmed identfication
  • 8878560
  • 9409733
• RefSeq identity
  • NM_005226
• Classification
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000020173

Gene info

• Identity
  HGNC:14298
• Gene
  LPAR3
• Long gene name
  lysophosphatidic acid receptor 3
• Synonyms gene
  • EDG7
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
• Synonyms
  • LP-A3
  • Edg-7
  • RP4-678I3
  • HOFNH30
  • LPA3
• GenBank acession
  • AF127138
• Locus
  1p22.3
• Discovery year
  2001-01-02
• Entrez gene record
  23566
• Pubmed identfication
  • 10488122
• RefSeq identity
  • NM_012152
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000009925

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

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