TRPM8 Antibody

• Catalog number
  F41678-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TRPM8
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, IF, WB, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50
• Notes
  Titration of the TRPM8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TRPM8 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q7Z2W7
• Purity
  Purified
• Description
  Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
• Immunogen
  A portion of amino acids 263-292 from the human protein was used as the immunogen for this TRPM8 antibody.
• Storage
  Aliquot the TRPM8 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TRPM8  
• Gene symbol
  TRPM8
• Short name
  Anti-TRPM8
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to TRPM8
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17961
• Gene
  TRPM8
• Long gene name
  transient receptor potential cation channel subfamily M member 8
• Synonyms gene name
  • transient receptor potential cation channel, subfamily M, member 8
• GenBank acession
  • AC005538
• Locus
  2q37.1
• Discovery year
  2002-01-11
• Entrez gene record
  79054
• Pubmed identfication
  • 16382100
• RefSeq identity
  • NM_024080
• Classification
  • Transient receptor potential cation channels
• VEGA ID
  OTTHUMG00000059129

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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