TRIF Antibody / TICAM1

• Catalog number
  R32274
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TRIF / TICAM1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the TRIF antibody should be determined by the researcher.
• Intented use
  This TRIF antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q80UF7
• Purity
  Antigen affinity
• Description
  TICAM1 (TIR domain containing adaptor molecule 1), also known as TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al. (2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al. (2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2. Small interfering (si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
• Immunogen
  Amino acids QDTEARVSLESLKMNTVAQLVAHQWADMETTE of mouse TRIF were used as the immunogen for the TRIF antibody.
• Storage
  After reconstitution, the TRIF antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TRIF   TICAM1  
• Gene symbol
  TICAM1, TRIM69
• Short name
  Anti-TRIF / TICAM1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TRIF / TICAM1
• Alternative technique
  antibodies
• Alternative to gene target
  toll-like receptor adaptor molecule 1, TICAM1 and IDBG-19505 and ENSG00000127666 and 148022, protein kinase binding, Cytoplasm, Ticam1 and IDBG-191912 and ENSMUSG00000047123 and 106759, BT.47460 and IDBG-644220 and ENSBTAG00000019966 and 510427

Gene info

• Identity
  HGNC:18348
• Gene
  TICAM1
• Long gene name
  toll like receptor adaptor molecule 1
• Synonyms gene name
  • toll-like receptor adaptor molecule 1
• Synonyms
  • TRIF
  • TICAM-1
  • MGC35334
  • PRVTIRB
• Synonyms name
  • TIR domain-containing adapter molecule 1
  • TIR domain-containing adaptor-inducing interferon-β
• GenBank acession
  • AB086380
• Locus
  19p13.3
• Discovery year
  2005-06-27
• Entrez gene record
  148022
• Pubmed identfication
  • 12539043
  • 12471095
• RefSeq identity
  • NM_014261
• Classification
  • TIR domain containing
• VEGA ID
  OTTHUMG00000180248
• Locus Specific Databases
  • LRG_358

Gene info

• Identity
  HGNC:17857
• Gene
  TRIM69
• Long gene name
  tripartite motif containing 69
• Synonyms gene
  • RNF36
• Synonyms gene name
  • ring finger protein 36
  • tripartite motif-containing 69
• Synonyms
  • Trif
  • TRIMLESS
• GenBank acession
  • AF302088
• Locus
  15q15-q21
• Discovery year
  2002-01-10
• Classification
  • Ring finger proteins
  • Tripartite motif containing
• VEGA ID
  OTTHUMG00000131246

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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