TREM1 Antibody

• Catalog number
  R30663
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TREM1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, IHC-F
• Recommended dilutions
  Western blot: 0.5-1ug/ml (1),IHC (Paraffin): 0.5-1ug/ml,IHC (Frozen): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the TREM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The chimeric recombinant protein used for testing contains AA 21-202 + human Fc and is glycosylated.
• Intented use
  This TREM1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9JKE2
• Purity
  Antigen affinity
• Description
  Triggering receptor expressed on myeloid cells-1, is encoded by TREM1 gene. Expression is seen is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide(LPS), gram-negative bacteria, and fungi. Cross-linking of TREM1 on neutrophils induces interleukin-8(IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1(MCP1, or SCYA2) and tumor necrosis factor(TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Engagement also induces upregulation of adhesion molecules(e.g., ITGB1) and costimulatory molecules(e.g., CD40). TREM1 is associated with DAP12(TYROBP), a molecule frequently associated with activating receptors.
• Immunogen
  Amino acids 74-90 (FTRPSEVHMGKFTLKHD-mouse) were used as the immunogen for this TREM1 antibody.
• Storage
  After reconstitution, the TREM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TREM1  
• Gene symbol
  TREM1
• Short name
  Anti-TREM1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TREM1
• Alternative technique
  antibodies
• Alternative to gene target
  triggering receptor expressed on myeloid cells 1, TREM1 and IDBG-86629 and ENSG00000124731 and 54210, scaffold protein binding, Extracellular, Trem1 and IDBG-189794 and ENSMUSG00000042265 and 58217, TREM1 and IDBG-630874 and ENSBTAG00000017593 and 404547

Gene info

• Identity
  HGNC:17760
• Gene
  TREM1
• Long gene name
  triggering receptor expressed on myeloid cells 1
• Synonyms
  • TREM-1
  • CD354
• GenBank acession
  • AF196329
• Locus
  6p21.1
• Discovery year
  2002-08-09
• Entrez gene record
  54210
• Pubmed identfication
  • 11922939
  • 10799849
• RefSeq identity
  • NM_018643
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000014674

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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