TRAF2 Antibody
-
Catalog numberR31114
-
PricePlease ask
-
Size0.1mg
-
-
CategoryAntibody
-
Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
-
FormAntigen affinity purified
-
ConjugationUnconjugated
-
ClonePolyclonal antibody
-
Recognised antigenTRAF2
-
Host animalRabbit (Oryctolagus cuniculus)
-
ClonalityPolyclonal (rabbit origin)
-
Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
-
Tested applicationsWB, IHC-P
-
Recommended dilutionsWestern blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
-
NotesThe stated application concentrations are suggested starting amounts. Titration of the TRAF2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
Intented useThis TRAF2 antibodyis to be used only for research purposes and not for diagnostics..
-
UniprotQ12933
-
PurityAntigen affinity
-
DescriptionTNF Receptor-Associated Factor 2, also called TRAP, is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor(TNFR) associated factor(TRAF) protein family. It is a common signal transducer for TNFR2 and CD40 that mediates activation of NF-kappa-B. Rothe et al.(1996) identified ITRAF, which binds to TRAF1, TRAF2, and TRAF3, and that when overexpressed inhibits TRAF2-mediated NF-kappa-B activation. They proposed that ITRAF is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Kanamori et al.(2002) found that mouse Traf2 interacted directly with T2bp, and they presented evidence that T2BP is involved in TNF-mediated signaling by its interaction with TRAF2.
-
ImmunogenAn amino acid sequence from the middle region of human TNF Receptor-Associated Factor 2 (RQHRLDQDKIEALSSKVQQLE) was used as the immunogen for this TRAF2 antibody.
-
StorageAfter reconstitution, the TRAF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
-
PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolTRAF2, TANK
-
Short nameAnti-TRAF2
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit IgG
-
Alternative nameAntibodies to TRAF2
-
Alternative techniqueantibodies
-
Alternative to gene targetTNF receptor-associated factor 2, MGC:45012 and TRAP and TRAP3, TRAF2 and IDBG-92817 and ENSG00000127191 and 7186, metal ion binding, Plasma membranes, Traf2 and IDBG-146254 and ENSMUSG00000026942 and 22030, TRAF2 and IDBG-641438 and ENSBTAG00000010497 and 512355
-
Gene info
-
Identity
-
Gene
-
Long gene nameTNF receptor associated factor 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-04-28
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- TNF receptor associated factors
- MicroRNA protein coding host genes
- Ring finger proteins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameTRAF family member associated NFKB activator
-
Synonyms gene
-
Synonyms gene name
- TRAF family member-associated NFKB activator
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1997-06-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data