TIE1 Antibody

• Catalog number
  F50681-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TIE1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the TIE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TIE1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P35590
• Purity
  Purified
• Description
  Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
• Immunogen
  A portion of amino acids 12-42 from the human protein was used as the immunogen for this TIE1 antibody.
• Storage
  Aliquot the TIE1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TIE1  
• Gene symbol
  TIE1
• Short name
  Anti-TIE1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to TIE1
• Alternative technique
  antibodies
• Alternative to gene target
  tyrosine kinase with immunoglobulin-like and EGF-like domains 1, JTK14 and TIE, TIE1 and IDBG-97374 and ENSG00000066056 and 102724932,7075, transferase activity, Plasma membranes, Tie1 and IDBG-181621 and ENSMUSG00000033191 and 21846, TIE1 and IDBG-640485 and ENSBTAG00000003777 and 280941

Gene info

• Identity
  HGNC:11809
• Gene
  TIE1
• Long gene name
  tyrosine kinase with immunoglobulin like and EGF like domains 1
• Synonyms gene
  • TIE
• Synonyms gene name
  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
• Synonyms
  • JTK14
• GenBank acession
  • BC038239
• Locus
  1p34.2
• Discovery year
  1993-08-24
• Entrez gene record
  7075
• Pubmed identfication
  • 1312667
• RefSeq identity
  • NM_005424
• Classification
  • Immunoglobulin like domain containing
  • Receptor tyrosine kinases
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000007282

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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