TERT Antibody

• Catalog number
  R30782
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TERT
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the TERT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TERT antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O70372
• Purity
  Antigen affinity
• Description
  TERT (Telomerase reverse transcriptase), is a catalytic subunit of the enzyme telomerase. Its absence(usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat. The TERT gene was mapped to chromosome 5p15.33T by Meyerson, M. Elomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
• Immunogen
  An amino acid sequence from the N-terminus of mouse Telomerase reverse transcriptase (15-30aa RSRYREVWPLATFVRR) was used as the immunogen for this TERT antibody (100% rat homology).
• Storage
  After reconstitution, the TERT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TERT  
• Gene symbol
  TERT
• Short name
  Anti-TERT
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TERT
• Alternative technique
  antibodies
• Alternative to gene target
  telomerase reverse transcriptase, CMM9 and DKCA2 and DKCB4 and EST2 and hEST2 and hTRT and PFBMFT1 and TCS1 and TP2 and TRT, TERT and IDBG-10998 and ENSG00000164362 and 7015, telomeric RNA binding, nuclei, Tert and IDBG-165912 and ENSMUSG00000021611 and 21752, BT.60929 and IDBG-632169 and ENSBTAG00000012567 and 518884

Gene info

• Identity
  HGNC:11730
• Gene
  TERT
• Long gene name
  telomerase reverse transcriptase
• Synonyms
  • TRT
  • TP2
  • TCS1
  • hEST2
  • EST2
• GenBank acession
  • AF015950
• Locus
  5p15.33
• Discovery year
  1998-01-21
• Pubmed identfication
  • 9252327
• VEGA ID
  OTTHUMG00000090357
• Locus Specific Databases
  • LRG_343

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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