SUV39H2 Antibody (KTM1B)

• Catalog number
  F47078-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SUV39H2 (KTM1B)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SUV39H2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9H5I1
• Purity
  Antigen affinity
• Description
  Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
• Immunogen
  A portion of amino acids 367-395 from the human protein was used as the immunogen for this SUV39H2 antibody.
• Storage
  Aliquot the SUV39H2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SUV39H2   KTM1B  
• Gene symbol
  SUV39H2-DT, SUV39H2
• Short name
  Anti-SUV39H2 (KTM1B)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to SUV39H2 (KTM1B)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55188
• Gene
  SUV39H2-DT
• Long gene name
  SUV39H2 divergent transcript
• Locus
  10p13
• Discovery year
  2020-08-12
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:17287
• Gene
  SUV39H2
• Long gene name
  SUV39H2 histone lysine methyltransferase
• Synonyms gene name
  • suppressor of variegation 3-9 homolog 2 (Drosophila)
  • suppressor of variegation 3-9 homolog 2
• Synonyms
  • FLJ23414
  • KMT1B
• Synonyms name
  • histone methyltransferase SUV39H2
• GenBank acession
  • AK027067
• Locus
  10p13
• Discovery year
  2003-11-11
• Entrez gene record
  79723
• Pubmed identfication
  • 11094092
• RefSeq identity
  • NM_024670
• Classification
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000017718

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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