STAT5b Antibody

• Catalog number
  R32128
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  STAT5b
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the STAT5b antibody should be determined by the researcher.
• Intented use
  This STAT5b antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P51692
• Purity
  Antigen affinity
• Description
  STAT5B (Signal transducer and activator of transcription 5B) is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available. By FISH, Lin et al. (1996) mapped STAT5B to 17q11.2. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.
• Immunogen
  Amino acids KDEVYSKYYTPVPCESATAKAVDGYVKPQ of human STAT5b were used as the immunogen for the STAT5b antibody.
• Storage
  After reconstitution, the STAT5b antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  STAT5b  
• Gene symbol
  STAT5B
• Short name
  Anti-STAT5b
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to STAT5b
• Alternative technique
  antibodies
• Alternative to gene target
  signal transducer and activator of transcription 5B, STAT5, STAT5B and IDBG-50532 and ENSG00000173757 and 102723386,6777, protein dimerization activity, nuclei, Stat5b and IDBG-211594 and ENSMUSG00000020919 and 20851, STAT5B and IDBG-640180 and ENSBTAG00000010125 and 282376,789476

Gene info

• Identity
  HGNC:11367
• Gene
  STAT5B
• Long gene name
  signal transducer and activator of transcription 5B
• GenBank acession
  • BC065227
• Locus
  17q21.2
• Discovery year
  1997-01-28
• Entrez gene record
  6777
• Pubmed identfication
  • 8631883
• RefSeq identity
  • NM_012448
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000150724
• Locus Specific Databases
  • STAT5Bbase: Mutation registry for Growth hormone insensitivity with immunodeficiency
  • Global Variome shared LOVD
  • LRG_192

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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