SPTLC1 Antibody

• Catalog number
  R30870
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SPTLC1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the SPTLC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SPTLC1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O15269
• Purity
  Antigen affinity
• Description
  Serine palmitoyltransferase, long chain base subunit 1, also known as SPT1, LCB1, is a protein which in humans is encoded by the SPTLC1 gene. Dawkins et al.(2001)noted that the gene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
• Immunogen
  An amino acid sequence from the middle region of human SPTLC1 (FYGTFDVHLDLEDRLAK) was used as the immunogen for this SPTLC1 antibody.
• Storage
  After reconstitution, the SPTLC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SPTLC1  
• Gene symbol
  SPTLC1
• Short name
  Anti-SPTLC1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to SPTLC1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11277
• Gene
  SPTLC1
• Long gene name
  serine palmitoyltransferase long chain base subunit 1
• Synonyms gene
  • HSN1
• Synonyms gene name
  • hereditary sensory neuropathy, type 1
• Synonyms
  • LCB1
  • SPTI
  • HSAN1
  • hLCB1
• GenBank acession
  • Y08685
• Locus
  9q22.31
• Discovery year
  2000-07-31
• Entrez gene record
  10558
• Pubmed identfication
  • 9363775
• RefSeq identity
  • NM_006415
• VEGA ID
  OTTHUMG00000021047
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_272

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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